4637-24-5
Chemical Structure
DMF-DMA
Synonym(s): N-Dimethoxymethyl-N,N-dimethylamine
- CAS No.: 4637-24-5
- Formula:C5H13NO2
- Molecular Weight:119.16
IUPAC Name: 1,1-dimethoxy-N,N-dimethylmethanamine
InChIKey: ZSXGLVDWWRXATF-UHFFFAOYSA-N
SMILES: CN(C)C(OC)OC
Biological Activity: DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate[1][2].
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DMF-DMA | 97.0% | DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate. | ||||||||||||||||||||
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- [1]. Gümüş M, Koca İ. Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF‐DMA Reagent with Different Functional Groups[J]. ChemistrySelect, 2020, 5(40): 12377-12397.
- [2]. Xu A, et al. Development of Diallylimidazolium Methoxyacetate/DMSO (DMF/DMA) Solvents for Improving Cellulose Dissolution and Fabricating Porous Material. Polymers (Basel). 2019;11(5):845. Published 2019 May 10. [Content Brief]
Keywords
