64 Results for "

screen

" in MedChemExpress (MCE) Product Catalog:
Products (64)

64 Results for "screen" in MCE Product Catalog:

6
CPI-203
CPI-203
0 Images
6 Publications Verification
Art. -Nr.: HY-15846
CAS. Nr.: 1446144-04-2
Reinheit:  98.98%
Target:  

Epigenetic Reader Domain Apoptosis

Forschungsgebiete:  

Cancer

CPI-203 is a novel potent, selective and cell permeable inhibitor of BET bromodomain, with an IC50 value of appr 37 nM (BRD4 α-screen assay).
5
Fluorescein-5-maleimide
Fluorescein-5-maleimide
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5 Cited Publications
Art. -Nr.: HY-D0098
CAS. Nr.: 75350-46-8
Synonyms: N-(5-Fluoresceinyl)maleimide
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .
5
CCT251236
CCT251236
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5 Cited Publications
Art. -Nr.: HY-101026
CAS. Nr.: 1693731-40-6
Reinheit:  98.82%
Target:  

HSP

Forschungsgebiete:  

Cancer

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.
1
Glabrone
Glabrone
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1 Cited Publications
Art. -Nr.: HY-N4194
CAS. Nr.: 60008-02-8
Category:  

Flavonoids Leguminosae Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones

Target:  

PPAR Influenza Virus

Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .
1
RN-1665
RN-1665
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1 Cited Publications
Art. -Nr.: HY-160900
CAS. Nr.: 1803003-65-7
Target:  

TRP Channel

Forschungsgebiete:  

Others

RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively .
1
Scaff10-8
Scaff10-8
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1 Cited Publications
Art. -Nr.: HY-121667
CAS. Nr.: 777857-56-4
Target:  

ROCK

Forschungsgebiete:  

Neurological Disease Endocrinology

Scaff10-8 is a RhoA inhibitor. Scaff10-8 binds to RhoA, inhibits AKAP-Lbc-mediated RhoA activation. Scaff10-8 can be used for research on diabetes insipidus and bipolar disorder .
Hippuryl-His-Leu-OH hydrate
Hippuryl-His-Leu-OH hydrate
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Art. -Nr.: HY-137875
CAS. Nr.: 207386-83-2
Reinheit:  98.60%
Synonyms: N-Benzoyl-Gly-His-Leu hydrate
Target:  

Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives

Forschungsgebiete:  

Cardiovascular Disease

Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) hydrate is a specific substrate for angiotensin-converting enzyme ACE I and is a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH hydrate is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH hydrate undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The His-Leu released from Hippuryl-His-Leu-OH hydrate can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH hydrate can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of changes in ACE activity during physiological and pathological processes such as renal compensatory hypertrophy .
X-alpha-Gal
X-alpha-Gal
0 Images
Art. -Nr.: HY-114522
CAS. Nr.: 107021-38-5
Reinheit:  99.93%
Target:  

Biochemical Assay Reagents

Forschungsgebiete:  

Others

X-alpha-Gal is a chromogenic substrate that is used to screen colonies with high activity of β-galactopyranoside. X-alpha-Gal also detects α-galactosidase activity. X-alpha-Gal can be used in yeast two hybrid screening for MEL1 gene activation. X-alpha-Gal can be used with Matchmaker GAL4-based products to confirm protein interactions .
Monobenzyl phthalate
Monobenzyl phthalate
0 Images
Art. -Nr.: HY-W011848
CAS. Nr.: 2528-16-7
Synonyms: 2-((Benzyloxy)carbonyl)benzoic acid
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite

Monobenzyl phthalate is a phthalate metabolite (aromatic alkyl chain monophthalate) with oral activity, which acts as a male reproductive development inhibitor and antiandrogen in rat fetuses .
TC LPA5 4
TC LPA5 4
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Art. -Nr.: HY-107615
CAS. Nr.: 1393814-38-4
Reinheit:  99.69%
Target:  

LPL Receptor

Forschungsgebiete:  

Cancer

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets . TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells .
Neoglycyrol
Neoglycyrol
0 Images
Art. -Nr.: HY-N3961
CAS. Nr.: 23013-84-5
Category:  

Cardiovascular Disease Leguminosae Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Others

Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .
Meldola blue
Meldola blue
0 Images
Art. -Nr.: HY-D0808
CAS. Nr.: 7057-57-0
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.
Fluorescein-CM2
Fluorescein-CM2
0 Images
Art. -Nr.: HY-D2277
CAS. Nr.: 1394821-44-3
Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)
0 Images
Art. -Nr.: HY-164190
Target:  

DNA/RNA Synthesis

Forschungsgebiete:  

Others

m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
CP-447697
CP-447697
0 Images
Art. -Nr.: HY-112199
CAS. Nr.: 1092847-21-6
Reinheit:  99.70%
Target:  

Complement System

Forschungsgebiete:  

Inflammation/Immunology

CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation .
And1-IN-1
And1-IN-1
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Art. -Nr.: HY-150184
CAS. Nr.: 2451028-69-4
Reinheit:  98.01%
Target:  

DNA/RNA Synthesis

Forschungsgebiete:  

Cancer

And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer .
Quizalofop
Quizalofop
0 Images
Art. -Nr.: HY-123307
CAS. Nr.: 76578-12-6
Reinheit:  98.03%
Synonyms: Xylafop
Target:  

Environmental Pollutants Acetyl-CoA Carboxylase

Forschungsgebiete:  

Others

Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production .
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside
0 Images
Art. -Nr.: HY-123000
CAS. Nr.: 124223-99-0
Reinheit:  ≥99.0%
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorogenic substrate for studying the enzymatic activity of α-galactosidase. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is used to analyze enzyme activity in various biological samples, helping scientists gain insight into the function of the enzyme in vivo. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside can also be used to screen potential compounds to inhibit or activate this enzyme.
Hippuryl-His-Leu-OH
Hippuryl-His-Leu-OH
0 Images
Art. -Nr.: HY-P4551
CAS. Nr.: 31373-65-6
Synonyms: N-Benzoyl-Gly-His-Leu
Target:  

Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives

Forschungsgebiete:  

Cardiovascular Disease

Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) is a specific substrate for angiotensin-converting enzyme (ACE I) and a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The released His-Leu can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of ACE activity changes in physiological and pathological processes such as renal compensatory hypertrophy .
Ftase inhibitor III
Ftase inhibitor III
0 Images
Art. -Nr.: HY-142655
CAS. Nr.: 2710375-18-9
Target:  

Farnesyl Transferase

Forschungsgebiete:  

Infection

Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen.
Assay Types