2. GPCR/G Protein
  3. LPL Receptor
  4. TC LPA5 4

TC LPA5 4 

Cat. No.: HY-107615 Purity: 99.22%
COA Handling Instructions

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.

For research use only. We do not sell to patients.

TC LPA5 4 Chemical Structure

TC LPA5 4 Chemical Structure

CAS No. : 1393814-38-4

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Based on 1 publication(s) in Google Scholar

TC LPA5 4 Related Antibodies

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Description

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets[1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells[2].

In Vitro

TC LPA5 4 inhibits the proliferation on thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP, and BHT101 significantly with IC50 at 103.0 μM, 84.9 μM, 55.9μM, and 57.17 μM. TC LPA5 4 (5 μM; 24 hours) significantly inhibits LPA-stimulated migration of CGTH-W3 and TPC-1 cells, with an inhibitory rate of ~ 30%. B-CPAP and BHT101 cells expressed higher LPAR5 mRNA. TC LPA5 4 inhibits these two cell lines’ proliferations with IC50 at 55.9μM and 57.17 μM. CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA. TC LPA5 4 displays differential antitumor activity with IC50 at 103.0 μM and 84.9 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC LPA5 4 Related Antibodies
In Vivo

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) [2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 5 days/week for 2 weeks
Result: Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
Molecular Weight

410.89

Appearance

Solid

Formula

C23H23ClN2O3
CAS No.
SMILES

O=C(C1=NN(C2=CC=CC(OC)=C2)C(C3=CC=C(C4CCCCC4)C(Cl)=C3)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (152.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4337 mL 12.1687 mL 24.3374 mL
5 mM 0.4867 mL 2.4337 mL 4.8675 mL
10 mM 0.2434 mL 1.2169 mL 2.4337 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.06 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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TC LPA5 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

TC LPA5 41393814-38-4LPL ReceptorLysophospholipid ReceptoraggregationplateletRH7777CGTH-W3thyroidcancerInhibitorinhibitorinhibit

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