1. GPCR/G Protein
  2. LPL Receptor
  3. TC LPA5 4

TC LPA5 4 

Cat. No.: HY-107615
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TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened drug targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.

For research use only. We do not sell to patients.

TC LPA5 4 Chemical Structure

TC LPA5 4 Chemical Structure

CAS No. : 1393814-38-4

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Description

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened drug targets[1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells[2].

In Vitro

TC LPA5 4 inhibits the proliferation on thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP, and BHT101 significantly with IC50 at 103.0 μM, 84.9 μM, 55.9μM, and 57.17 μM. TC LPA5 4 (5 μM; 24 hours) significantly inhibits LPA-stimulated migration of CGTH-W3 and TPC-1 cells, with an inhibitory rate of ~ 30%. B-CPAP and BHT101 cells expressed higher LPAR5 mRNA. TC LPA5 4 inhibits these two cell lines’ proliferations with IC50 at 55.9μM and 57.17 μM. CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA. TC LPA5 4 displays differential antitumor activity with IC50 at 103.0 μM and 84.9 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) [2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 5 days/week for 2 weeks
Result: Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
Molecular Weight

410.89

Formula

C₂₃H₂₃ClN₂O₃

CAS No.
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TC LPA5 4
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HY-107615
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