60008-02-8
Chemical Structure
Glabrone
- CAS No.: 60008-02-8
- Formula:C20H16O5
- Molecular Weight:336.34
IUPAC Name: 5',7-dihydroxy-2',2'-dimethyl-2'H,4H-[3,6'-bichromen]-4-one
InChIKey: COLMVFWKLOZOOP-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2O)=COC4=CC(O)=CC=C14
Biological Activity: Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glabrone | 99.08% | Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity. | ||||||||||||||||||||
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Similarity Score 0.82
HY-N3388Licoisoflavone B -
Similarity Score 0.77
HY-N0236Corylin -
Similarity Score 0.73
HY-N17601Parvisoflavone B -
Similarity Score 0.71
HY-N2857Alpinumisoflavone -
Similarity Score 0.71
HY-N1230Sophoraisoflavone A -
Similarity Score 0.69
HY-N3492Isoderrone -
Similarity Score 0.66
HY-N3882Eurycarpin A -
Similarity Score 0.66
HY-N16506Koparin -
Similarity Score 0.65
HY-W7495582′-Hydroxyformononetin -
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References
- [1]. Grienke U, et al. Computer-guided approach to access the anti-influenza activity of licorice constituents. J Nat Prod. 2014 Mar 28;77(3):563-70. [Content Brief]
- [2]. Kuroda M, et al. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010 Jan 15;18(2):962-70. [Content Brief]
- [3]. Kuang Y, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. Eur J Pharm Sci. 2021 Jun 1;161:105786. [Content Brief]
