2. Immunology/Inflammation
  3. Complement System
  4. CP-447697

CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.

For research use only. We do not sell to patients.

CP-447697 Chemical Structure

CP-447697 Chemical Structure

CAS No. : 1092847-21-6

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5 mg USD 95 In-stock
10 mg USD 150 In-stock
25 mg USD 320 In-stock
50 mg USD 525 In-stock
100 mg USD 820 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation[1].

IC50 & Target

IC50: 31 nM (C5a receptor)[1]
Molecular Weight

554.05

Formula

C29H26ClF2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C1)=CC=C1CCN(C(C2=CSC3=C2C=CC=C3)=O)C4CCN(C(NC5=CC=C(F)C=C5F)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (225.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8049 mL 9.0245 mL 18.0489 mL
5 mM 0.3610 mL 1.8049 mL 3.6098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8049 mL 9.0245 mL 18.0489 mL 45.1223 mL
5 mM 0.3610 mL 1.8049 mL 3.6098 mL 9.0245 mL
10 mM 0.1805 mL 0.9024 mL 1.8049 mL 4.5122 mL
15 mM 0.1203 mL 0.6016 mL 1.2033 mL 3.0082 mL
20 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2561 mL
25 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8049 mL
30 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5041 mL
40 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1281 mL
50 mM 0.0361 mL 0.1805 mL 0.3610 mL 0.9024 mL
60 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7520 mL
80 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5640 mL
100 mM 0.0180 mL 0.0902 mL 0.1805 mL 0.4512 mL
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CP-447697 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-4476971092847-21-6CP447697CP 447697Complement Systemlibrary screeninflammationlipophilicrapidly metabolizeInhibitorinhibitorinhibit

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