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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
single channel
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "single channel" in MCE Product Catalog:
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R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) .
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2 Cited Publications
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2 Cited Publications
Cat. No.: HY-113147B
Purity: ≥98.0%
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Cat. No.: HY-P5807A
Synonyms: β-Mammal toxin Cn2 TFA
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Cat. No.: HY-W014883
CAS No.: 2783-17-7
Synonyms: 1,12-DD; 1,12-Diamino dodecane
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1,12-Dodecanediamine (1,12-DD) is a reversible Maxi calcium-activated potassium channel blocker. 1,12-Dodecanediamine can reduce the single-channel current amplitude, mean channel open time, and channel open probability. 1,12-Dodecanediamine is promising for research of cell electrical signal transduction mechanism .
Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
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Cat. No.: HY-117174
CAS No.: 170228-29-2
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L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 μM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes .
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PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors .
Cat. No.: HY-113147S1
CAS No.: 2847775-90-8
Cat. No.: HY-113147AR
CAS No.: 18877-64-0
Cat. No.: HY-152013S
CAS No.: 2692623-98-4
Cat. No.: HY-D1756
CAS No.: 117491-83-5
Cat. No.: HY-D0968B
Synonyms: Cyanine3 triethylamine
Cat. No.: HY-P5917
CAS No.: 1373890-79-9
Synonyms: Vaejovis mexicanus peptide 24
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Cat. No.: HY-181128
CAS No.: 2253948-15-9
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QO-83, Retigabine analogue, is a voltage-gated potassium channel KCNQ2 (Kv7.2) activator with an EC50 of 0.56 μM. QO-83 binds to a single hydrophobic pocket of KCNQ2-CaM complex in closed conformation. QO-83 induces a negative shift in the voltage-dependent activation curve of KCNQ2 channels, increasing the channel's voltage sensitivity. QO-83 can be used for the research of epilepsies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
