2847775-90-8
Chemical Structure
L-Palmitoylcarnitine-d9
- CAS No.: 2847775-90-8
- Formula:C23H36D9NO4
- Molecular Weight:408.66
InChIKey: XOMRRQXKHMYMOC-NKVYTPEUSA-N
SMILES: CCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
Biological Activity: L-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1][1][2].
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L-Palmitoylcarnitine-d9 | 99.0% | L-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. | ||||||||||||||||||||
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L-Palmitoylcarnitine-13C,d3 | L-Palmitoylcarnitine-13C,d3 is the deuterated, 13C-labeled L-Palmitoylcarnitine (HY-113147). L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. | |||||||||||||||||||||
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L-Palmitoylcarnitine | 99.88% | L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. | ||||||||||||||||||||
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Similarity Score 1.00
HY-126357Palmitoylcarnitine -
Similarity Score 0.95
HY-113202Stearoylcarnitine -
Similarity Score 0.95
HY-113202ADL-Stearoylcarnitine -
Similarity Score 0.95
HY-113201RTetradecanoylcarnitine (Standard) -
Similarity Score 0.92
HY-101017AD-Palmitoylcarnitine chloride -
Similarity Score 0.92
HY-101017RPalmitoylcarnitine chloride (Standard) -
Similarity Score 0.92
HY-113147ARL-Palmitoylcarnitine chloride (Standard) -
Similarity Score 0.90
HY-113166Dodecanoylcarnitine -
Similarity Score 0.90
HY-165120Heptadecanoyl-L-carnitine chloride -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207. [Content Brief]
