Search Result
Results for "
spider
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-P1410
-
GsMTx4
Maximum Cited Publications
112 Publications Verification
|
TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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-
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- HY-P1410A
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GsMTx4 TFA
Maximum Cited Publications
112 Publications Verification
|
TRP Channel
Piezo Channel
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
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GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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- HY-P1410B
-
-
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- HY-W587486
-
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Endogenous Metabolite
Bacterial
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Metabolic Disease
|
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N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes .
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-
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- HY-12506A
-
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1-Naphthylacetyl spermine trihydrochloride
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iGluR
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Neurological Disease
|
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Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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-
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- HY-12506
-
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1-Naphthylacetyl spermine
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iGluR
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Neurological Disease
|
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Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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-
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- HY-P1411
-
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PcTx1; Psalmopoeus cambridgei toxin-1
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Sodium Channel
Apoptosis
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Neurological Disease
Cancer
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Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .
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-
-
- HY-P1410C
-
|
|
Piezo Channel
Calcium Channel
mTOR
PI3K
Akt
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
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D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca 2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .
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-
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- HY-W663938
-
|
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Parasite
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Others
|
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Cyflumetofen is a synthetic miticide that strongly inhibits mitochondrial complex II of spider mites, but not of insects, crustaceans, or mammals. Cyflumetofen is not significantly effective in inhibiting aflatoxin production in fungi .
|
-
-
- HY-W059342
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-
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- HY-P5786
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-
-
- HY-P3095
-
-
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- HY-138149
-
|
epi-Avermectin B1a
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Drug Metabolite
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Infection
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2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
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- HY-P1411A
-
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PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA
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Sodium Channel
Apoptosis
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Neurological Disease
Cancer
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Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .
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- HY-P5160A
-
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PhlTx1 TFA
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Sodium Channel
|
Neurological Disease
|
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Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
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-
-
- HY-P3655
-
|
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Calcium Channel
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Others
|
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Agelenin is a polypeptide composed of 35 amino acids. Agelenin could be isolated from the Agelenidae spider Agelena opulenta. Agelenin has structural similarity to insect-specific calcium channel inhibitor .
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-
-
- HY-B0828
-
|
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Parasite
Cholinesterase (ChE)
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Others
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Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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- HY-P1681A
-
|
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Sodium Channel
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Neurological Disease
|
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GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 TFA demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .
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- HY-P1681
-
|
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Sodium Channel
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Neurological Disease
|
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GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .
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- HY-P5162
-
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Sodium Channel
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Inflammation/Immunology
|
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Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .
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- HY-P2699
-
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GrTx; ω-GsTx SIA
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Calcium Channel
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Neurological Disease
|
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ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases .
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- HY-170513
-
|
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Insecticide
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Infection
Cancer
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3'-Ethoxy-5,6-dihydrospinosyn J 17-pseudoaglycone is a Spinosyn derivative with potent insecticidal activity. 3'-Ethoxy-5,6-dihydrospinosyn J 17-pseudoaglycone (500mg/L) achieves a 100% mortality rate against Mythimna separata, aphids, and red spiders .
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- HY-P5790
-
|
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Sodium Channel
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Neurological Disease
|
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μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II .
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-
-
- HY-129642
-
|
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Fungal
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Others
|
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Hirsutide is a cyclic tetrapeptide that can be found in spider-derived entomopathogenic fungus .
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-
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- HY-116511
-
|
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Parasite
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Infection
|
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Benzoximate is an acaricide that inhibits fruit tree red spider mite Panonychys ulmi (Koch) .
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- HY-172444
-
|
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Biochemical Assay Reagents
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Others
|
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Protein hydrolyzates, silk is a fibrous protein that can be produced by silkworms and spiders. Protein hydrolyzates, silk can be added to cosmetics .
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-
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- HY-P2785
-
-
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- HY-P2785A
-
-
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- HY-P1330
-
|
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P2X Receptor
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Inflammation/Immunology
|
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Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .
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- HY-W059342R
-
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YI-5301 (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Infection
|
|
Etoxazole (Standard) is the analytical standard of Etoxazole. This product is intended for research and analytical applications. Etoxazole (YI-5301) is an organofluorine insecticide widely used in agriculture. Etoxazole affects the nymphs, eggs, and larvae of spider mites by inhibiting chitin biosynthesis .
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- HY-W663938R
-
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Parasite
Reference Standards
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Others
|
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Cyflumetofen (Standard) is the analytical standard of Cyflumetofen. This product is intended for research and analytical applications. Cyflumetofen is a synthetic miticide that strongly inhibits mitochondrial complex II of spider mites, but not of insects, crustaceans, or mammals. Cyflumetofen is not significantly effective in inhibiting aflatoxin production in fungi .
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- HY-P5865
-
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Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a
|
Sodium Channel
|
Neurological Disease
|
|
Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects .
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-
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- HY-P5160
-
|
PhlTx1
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Sodium Channel
|
Neurological Disease
|
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Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
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- HY-P5770
-
|
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Sodium Channel
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Neurological Disease
|
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Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
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- HY-P5813
-
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β-TRTX-cd1a; β-Theraphotoxin-cd1a
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Calcium Channel
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Neurological Disease
|
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Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Cav2.2)(IC502.6 μM) and mouse sodium ion channels (Nav1.7). Cd1a can be used in the development of peripheral pain treatment drugs .
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- HY-P5153
-
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μ-TRTX-Tp1a
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Sodium Channel
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Neurological Disease
|
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ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
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- HY-100196AR
-
|
PQQ disodium salt (Standard); Methoxatin disodium salt (Standard)
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Reference Standards
Endogenous Metabolite
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Inflammation/Immunology
|
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Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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- HY-N10653
-
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(-)-Altemicidin
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Others
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Cancer
|
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Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
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- HY-B0828R
-
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Parasite
Reference Standards
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Others
|
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Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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- HY-P5164
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Sodium Channel
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Neurological Disease
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GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively . GrTx1 can be used for neurological disease research .
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- HY-100821
-
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Bacterial
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Infection
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2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes .
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- HY-B1167A
-
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Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride
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Others
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Cardiovascular Disease
|
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Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.
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- HY-W719544
-
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Parasite
|
Infection
|
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Cyenopyrafen is a mitochondrial complex II inhibitor and acaricide. Cyenopyrafen controls spider mites on fruit trees, vegetables and flowers .
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-
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- HY-P5142A
-
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ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA
|
Insecticide
Apoptosis
Calcium Channel
Necroptosis
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca 2+ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .
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- HY-182413
-
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Phospholipase
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Infection
|
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SMases D-IN-1 is an inhibitor of SMase D (sphingomyelinase D) from Loxosceles (brown recluse spider), with a Ki value of 0.54 μM. SMases D-IN-1 inhibits the hydrolysis of sphingomyelin substrates by recombinant and native SMases D, reduces the binding ability of SMases D to human red blood cells, and prevents the shedding of glycophorin C from the surface of human red blood cells. SMases D-IN-1 partially inhibits Loxosceles venom-induced death of human keratinocytes and also suppresses systemic reactions triggered by Loxosceles venom. SMases D-IN-1 can be used in studies related to recluse spider envenomation .
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- HY-P11136
-
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Bacterial
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Infection
|
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Latarcin 2a is a linear cationic antibacterial peptide that can be isolated from the venom of the spider Lachesana tarabaevi, with broad-spectrum antibacterial activity. Latarcin 2a has a MIC of 0.5 μM for both Bacillus subtilis and Escherichia coli. Latarcin 2a is often used in the research of infectious conditions .
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- HY-183930
-
|
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Insecticide
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Infection
|
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Anti-infective agent 13 is a naphthoquinone-based insecticide/acaricide. Anti-infective agent 13 exhibits insecticidal activity against Bemisia tabaci (sweetpotato whitefly) and Tetranychus urticae (two-spotted spider mite). Anti-infective agent 13 can be used in research related to insect and mite control .
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-
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- HY-B0828S
-
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Hostathion 40EC-d5; Hostathion-d5; Hostation-d5
|
Isotope-Labeled Compounds
Parasite
Cholinesterase (ChE)
|
Others
|
|
Triazophos-d5 (Hostathion 40EC-d5) is the deuterium labeled Triazophos(HY-B0828) . Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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- HY-W587486A
-
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Endogenous Metabolite
Bacterial
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Metabolic Disease
|
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N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes .
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- HY-N18035
-
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Insecticide
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Infection
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|
Spinosyn K is an insecticide found in the actinomycete Saccharopolyspora spinosa. Spinosyn K shows strong insecticidal activity .
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-
| Cat. No. |
Product Name |
Type |
-
- HY-W059342
-
|
YI-5301
|
Biochemical Assay Reagents
|
|
Etoxazole (YI-5301) is an organofluorine insecticide widely used in agriculture. Etoxazole affects the nymphs, eggs, and larvae of spider mites by inhibiting chitin biosynthesis .
|
-
- HY-W059342R
-
|
YI-5301 (Standard)
|
Biochemical Assay Reagents
|
|
Etoxazole (Standard) is the analytical standard of Etoxazole. This product is intended for research and analytical applications. Etoxazole (YI-5301) is an organofluorine insecticide widely used in agriculture. Etoxazole affects the nymphs, eggs, and larvae of spider mites by inhibiting chitin biosynthesis .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1410
-
GsMTx4
Maximum Cited Publications
112 Publications Verification
|
TRP Channel
Piezo Channel
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
|
-
- HY-P1410A
-
GsMTx4 TFA
Maximum Cited Publications
112 Publications Verification
|
TRP Channel
Piezo Channel
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
|
-
- HY-P1410B
-
-
- HY-P1411
-
|
PcTx1; Psalmopoeus cambridgei toxin-1
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Sodium Channel
Apoptosis
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Neurological Disease
Cancer
|
|
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .
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-
- HY-P1410C
-
|
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Piezo Channel
Calcium Channel
mTOR
PI3K
Akt
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca 2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .
|
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- HY-P5786
-
-
- HY-P3095
-
-
- HY-P1411A
-
|
PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA
|
Sodium Channel
Apoptosis
|
Neurological Disease
Cancer
|
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Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H + of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .
|
-
- HY-P5160A
-
|
PhlTx1 TFA
|
Sodium Channel
|
Neurological Disease
|
|
Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
|
-
- HY-P3655
-
|
|
Calcium Channel
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Others
|
|
Agelenin is a polypeptide composed of 35 amino acids. Agelenin could be isolated from the Agelenidae spider Agelena opulenta. Agelenin has structural similarity to insect-specific calcium channel inhibitor .
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- HY-P4525
-
|
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Peptides
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Others
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Ala-Ala-Ala-Ala is a poly-L-alanine (PLA) sequences. PLA is a kind of key element of the crystalline domains of spider dragline and wild silkworm silks .
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- HY-P1681A
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Sodium Channel
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Neurological Disease
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GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 TFA demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .
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- HY-P1681
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Sodium Channel
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Neurological Disease
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GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .
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- HY-P5162
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Sodium Channel
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Inflammation/Immunology
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Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .
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- HY-P2699
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GrTx; ω-GsTx SIA
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Calcium Channel
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Neurological Disease
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ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases .
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- HY-P5790
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Sodium Channel
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Neurological Disease
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μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II .
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- HY-P2785
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- HY-P2785A
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- HY-P5167
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Peptides
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Inflammation/Immunology
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GsAF-1 is a peptide toxin containing three disulfide bonds. GsAF-1 can be isolated from the venom of the Chilean pink tarantula. GsAF-1 can be used for research of moderate-to-severe pain .
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- HY-P1330
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P2X Receptor
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Inflammation/Immunology
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Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .
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- HY-P5865
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Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a
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Sodium Channel
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Neurological Disease
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Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects .
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- HY-P5160
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PhlTx1
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Sodium Channel
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Neurological Disease
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Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
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- HY-P5770
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Sodium Channel
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Neurological Disease
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Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
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- HY-P5813
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β-TRTX-cd1a; β-Theraphotoxin-cd1a
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Calcium Channel
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Neurological Disease
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Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Cav2.2)(IC502.6 μM) and mouse sodium ion channels (Nav1.7). Cd1a can be used in the development of peripheral pain treatment drugs .
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- HY-P5153
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μ-TRTX-Tp1a
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Sodium Channel
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Neurological Disease
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ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
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- HY-P5164
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Sodium Channel
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Neurological Disease
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GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively . GrTx1 can be used for neurological disease research .
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- HY-P5142A
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ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA
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Insecticide
Apoptosis
Calcium Channel
Necroptosis
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca 2+ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .
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- HY-P11136
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Bacterial
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Infection
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Latarcin 2a is a linear cationic antibacterial peptide that can be isolated from the venom of the spider Lachesana tarabaevi, with broad-spectrum antibacterial activity. Latarcin 2a has a MIC of 0.5 μM for both Bacillus subtilis and Escherichia coli. Latarcin 2a is often used in the research of infectious conditions .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-129642
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- HY-100196AR
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PQQ disodium salt (Standard); Methoxatin disodium salt (Standard)
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Quinones
Structural Classification
Microorganisms
Benzene Quinones
Endogenous metabolite
Source Classification
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Reference Standards
Endogenous Metabolite
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Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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- HY-100821
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- HY-B1167A
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Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride
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Rauvolfia verticillata (Lour.) Baill.
Apocynaceae
Natural Products
Plants
Source Classification
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Others
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Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.
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- HY-N18035
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0828S
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Triazophos-d5 (Hostathion 40EC-d5) is the deuterium labeled Triazophos(HY-B0828) . Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
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