MCH-1 antagonist 1
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.
For research use only. We do not sell to patients.
- CAS No.: 1039825-68-7
- Formula: C25H26N4O2
- Molecular Weight:414.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MCH-1 2.6 nM (Ki) |
CYP3A4 10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
14 nM
Compound: 7b
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Antagonistic activity at MCH-1 receptor expressed in CHO-K1 cell assessed as inhibition of MCH-induced calcium release
Antagonistic activity at MCH-1 receptor expressed in CHO-K1 cell assessed as inhibition of MCH-induced calcium release
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[PMID: 20961756] |
| HEK293 | IC50 |
2.5 μM
Compound: 7b
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Inhibition of human ERG expressed in HEK cells by mini-patch clamp assay
Inhibition of human ERG expressed in HEK cells by mini-patch clamp assay
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[PMID: 20961756] |
MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1039825-68-7
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Molecular Weight 414.50
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Formula C25H26N4O2
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SMILES
O=C1C=C(OCC2=CC=CC=C2)C=CN1C3=CC4=C(N(CCN5CCCC5)N=C4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MCH-1 antagonist 1 Related Classifications
HY-100331 Related Classifications
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