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Cat. No.: HY-124709

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TLR9 antagonist 2

TLR9 antagonist 2 is a highly selective and water-soluble TLR9 antagonist with an IC₅₀ of 13 nM against human TLR9. TLR9 antagonist 2 inhibits CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 antagonist 2 is applicable for research on systemic, TLR9-mediated uncontrolled inflammatory responses, such as sepsis.

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CAS No.: 1351978-48-7
Formule: C₂₅H₃₆N₆O₂
Masse moléculaire:452.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

TLR9 antagonist 2 Chemical Structure

CAS No.: 1351978-48-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

IL-6

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR) :

Voir tous les produits spécifiques à Isoform Interleukin Related :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>10 μM Compound: 18	Antagonist activity at human TLR8 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay Antagonist activity at human TLR8 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay	[PMID: 25408837]
HEK293	IC₅₀	>970 nM Compound: 18	Antagonist activity at human TLR7 transfected in HEK293 cells assessed as hydrolysis of pNPP after 24 hrs by SEAP reporter assay Antagonist activity at human TLR7 transfected in HEK293 cells assessed as hydrolysis of pNPP after 24 hrs by SEAP reporter assay	[PMID: 25408837]
HEK293	IC₅₀	13 nM Compound: 18	Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay	[PMID: 25408837]
PBMC	IC₅₀	244 nM Compound: 18	Inhibition of CpG-induced IL-6 production in human PBMC after 24 hrs by ELISA Inhibition of CpG-induced IL-6 production in human PBMC after 24 hrs by ELISA	[PMID: 25408837]
Splenocyte	IC₅₀	74 nM Compound: 18	Inhibition of CpG-induced IL-6 production in C57BL/6 mouse splenocytes after 24 hrs by ELISA Inhibition of CpG-induced IL-6 production in C57BL/6 mouse splenocytes after 24 hrs by ELISA	[PMID: 25408837]

In Vitro

TLR9 antagonist 2 (Compound 18) inhibits CpG-induced IL-6 production in mouse splenocytes (IC₅₀: 74 nM) and human peripheral blood mononuclear cells (PBMCs) (IC₅₀: 244 nM) in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TLR9 antagonist 2 inhibits CpG-induced IL-6 production in mouse peritoneal lavage fluid (PLF) and plasma (ED₅₀: 0.8 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1351978-48-7
Masse moléculaire 452.60
Formule C₂₅H₃₆N₆O₂
SMILES

OCCN1CCN(C=2C=CC(=CC2)C3=NC=C4C(=N3)N(CC4)CCCN5CCOCC5)CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Watanabe M, et a;. Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts. ACS Med Chem Lett. 2014 Oct 2;5(11):1235-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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