2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) Interleukin Related
  4. TLR9 antagonist 2

TLR9 antagonist 2 is a highly selective and water-soluble TLR9 antagonist with an IC50 of 13 nM against human TLR9. TLR9 antagonist 2 inhibits CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 antagonist 2 is applicable for research on systemic, TLR9-mediated uncontrolled inflammatory responses, such as sepsis.

For research use only. We do not sell to patients.

TLR9 antagonist 2

TLR9 antagonist 2 Chemical Structure

CAS No. : 1351978-48-7

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TLR9 antagonist 2 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

TLR9 antagonist 2 is a highly selective and water-soluble TLR9 antagonist with an IC50 of 13 nM against human TLR9. TLR9 antagonist 2 inhibits CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 antagonist 2 is applicable for research on systemic, TLR9-mediated uncontrolled inflammatory responses, such as sepsis[1].

IC50 & Target[1]

IL-6

 

In Vitro

TLR9 antagonist 2 (Compound 18) inhibits CpG-induced IL-6 production in mouse splenocytes (IC50: 74 nM) and human peripheral blood mononuclear cells (PBMCs) (IC50: 244 nM) in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TLR9 antagonist 2 Related Antibodies
In Vivo

TLR9 antagonist 2 inhibits CpG-induced IL-6 production in mouse peritoneal lavage fluid (PLF) and plasma (ED50: 0.8 mg/kg)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

452.60

Formula

C25H36N6O2
CAS No.
SMILES

OCCN1CCN(C=2C=CC(=CC2)C3=NC=C4C(=N3)N(CC4)CCCN5CCOCC5)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR9 antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR9 antagonist 21351978-48-7Toll-like Receptor (TLR)Interleukin RelatedILTLR9IL-6sepsisInhibitorinhibitorinhibit

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