1351978-48-7
Chemical Structure
TLR9 antagonist 2
- CAS 番号: 1351978-48-7
- Formula:C25H36N6O2
- Molecular Weight:452.60
IUPAC Name: 2-(4-(4-(7-(3-morpholinopropyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl)phenyl)piperazin-1-yl)ethan-1-ol
InChIKey: VQQGQCSLCPMKAG-UHFFFAOYSA-N
SMILES: OCCN1CCN(C=2C=CC(=CC2)C3=NC=C4C(=N3)N(CC4)CCCN5CCOCC5)CC1
Biological Activity: TLR9 antagonist 2 is a highly selective and water-soluble TLR9 antagonist with an IC50 of 13 nM against human TLR9. TLR9 antagonist 2 inhibits CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 antagonist 2 is applicable for research on systemic, TLR9-mediated uncontrolled inflammatory responses, such as sepsis[1].
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TLR9 antagonist 2 | TLR9 antagonist 2 is a highly selective and water-soluble TLR9 antagonist with an IC50 of 13 nM against human TLR9. TLR9 antagonist 2 inhibits CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 antagonist 2 is applicable for research on systemic, TLR9-mediated uncontrolled inflammatory responses, such as sepsis. | |||||||||||||||||||||
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