1. GPCR/G Protein
  2. Adenosine Receptor
  3. Trabodenoson

Trabodenoson (Synonyms: INO-8875)

Cat. No.: HY-106007 Purity: 98.14%
Handling Instructions

Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma.

For research use only. We do not sell to patients.

Trabodenoson Chemical Structure

Trabodenoson Chemical Structure

CAS No. : 871108-05-3

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5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma[1].

In Vitro

Trabodenoson treatment significantly increaseS MMP-2 activity and MMP-14 abundance, while decreasing fibronectin and collagen IV expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trabodenoson (6.0%), demonstrating an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation)[1].
Topical trabodenoson significantly upregulates nestin expression in the ONH of induced eyes compared with vehicle-treated no-induced eyes[2].
Trabodenoson-treated eyes have significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. RGC counts are higher in Trabodenoson-treated eyes compared to vehicle (74% versus 47% of the contralateral eye)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young (3-4 months old) and aged (12 months old)[1].
Dosage: 3% or 6% in 10 μL.
Administration: Eye drop for 7 consecutive days.
Result: Decreased IOP.
Animal Model: Rats[2].
Dosage: 3%.
Administration: Topical delivery daily.
Result: Had significantly reduced optic nerve (ON) edema.
Clinical Trial
Molecular Weight

380.36

Formula

C₁₅H₂₀N₆O₆

CAS No.
SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](CO[N+]([O-])=O)[[email protected]]1O)N2C3=NC=NC(NC4CCCC4)=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (328.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6291 mL 13.1454 mL 26.2909 mL
5 mM 0.5258 mL 2.6291 mL 5.2582 mL
10 mM 0.2629 mL 1.3145 mL 2.6291 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TrabodenosonINO-8875INO8875INO 8875Adenosine ReceptorP1 receptorPrimaryOpen-AngleGlaucomacollagenInhibitorinhibitorinhibit

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Product Name:
Trabodenoson
Cat. No.:
HY-106007
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