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ODN 1826

(Synonyms: CpG 1826)
12 Cited Publications
Customer Review

Based on 12 publication(s) in Google Scholar

ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 induces NO and iNOS production and enhances Apoptosis. ODN 1826 enhances immune surveillance. ODN 1826 increases aortic atherosclerotic plaque size. ODN 1826 has antitumor activity against lung cancer, glioma and melanoma.

For research use only. We do not sell to patients.

  • Purity: 99.51%
  • CAS No.: 202668-42-6
  • Molecular Weight:6364.10
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • ODN 1826 Chemical Structure
    ODN 1826 Chemical Structure
  • Experimental Validation Results for ODN 1826
  • Experimental Validation Results for ODN 1826
  • Experimental Validation Results for ODN 1826
  • Experimental Validation Results for ODN 1826
  • Experimental Validation Results for ODN 1826
  • Experimental Validation Results for ODN 1826
CAS No.: 202668-42-6
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) ODN 1826

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Customer Validation & Images
Cell Proliferation/Viability AssayRT-PCRHistological Imaging/StainingApoptosis AnalysisWB
  • RT-PCR
  • Cell Proliferation/Viability Assay
  • Histological Imaging/Staining
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • WB

All Toll-like Receptor (TLR) Isoforms

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All NO Synthase Isoforms

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Assay Types
  • ODN 1826 Chemical Structure
    ODN 1826 Chemical Structure DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T)
    1/16
  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Sep 1:e02375. [Abstract]

    Customer Validation
     ODN 1826 (CpG, 500 ng per well; 24 h) significantly promoted the repolarization of M2-typed bone marrow-derived cells (BMDM), which stood for tumor-associated macrophages (TAM), with a significant increase of M1 (iNOS) and a decrease of M2 markers (Fizz1 and Mrc1).

  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Life Sci. 2025 Nov 1:380:123930. [Abstract]

    Customer Validation
     Cytotoxicity analysis of DC 2.4 cells treated with DNA-OprF/PcrV + CpG (ODN 1826) for 24 h. CpG was functionally integrated with the DNA vaccine via physical mixing. Specifically, 10 μg of pVAX1-OprF, 10 μg of pVAX1-PcrV, and 10 μg of CpG ODN were vortex-mixed in 150 μl of 1640 medium, followed by the addition of 60 μl of transfection reagent (mass-to-volume ratio = 1:2). The mixture was incubated at room temperature for 30 min to form transfection complexes, sterilized by passage through a 0.22 μm filter, and used immediately.

  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Life Sci. 2025 Nov 1:380:123930. [Abstract]

    Customer Validation
     ODN 1826 (CpG, 0.1 μg/μL; s.c.; 200 μL injected every 2 weeks for a total of three times).
    HE-stained image of pathological sections of the heart, liver, lung, and kidney after immunization (100×). Scale bar = 50 μm. These results revealed no obvious tissue pathological changes or inflammatory cell infiltration in the four treatment groups, including the DNA-OprF/PcrV + CpG group.

  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2025 Sep 5;50(5):288. [Abstract]

    Customer Validation
     ODN 1826 (CpG) regulate astrocyte cell viability and TLR9/NF-κB pathway activation. Human astrocytes were treated with varying concentrations of CpG oligodeoxynucleotides (0, 100, 1000, and 5000 ng/mL) for 24 h. Cell viability was assessed using CCK-8 assay.

  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2025 Sep 5;50(5):288. [Abstract]

    Customer Validation
     ODN 1826 (CpG) regulate astrocyte cell viability and TLR9/NF-κB pathway activation. Human astrocytes were treated with varying concentrations of CpG oligodeoxynucleotides (0, 100, 1000, and 5000 ng/mL) for 24 h. Apoptosis rates were determined by flow cytometry analysis using Annexin V-FITC and propidium iodide staining.

  • 1/16

    ODN 1826 purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2025 Sep 5;50(5):288. [Abstract]

    Customer Validation
     ODN 1826 (CpG) regulate astrocyte cell viability and TLR9/NF-κB pathway activation. Human astrocytes were treated with varying concentrations of CpG oligodeoxynucleotides (0, 100, 1000, and 5000 ng/mL) for 24 h. Protein expression levels of TLR9, total NF-κB, and phosphorylated NF-κB (p-NF-κB) were analyzed by Western blot with GAPDH as loading control.

  • DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T)