α-MSH (11-13)
α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 67727-97-3
- Formula: C16H30N4O4
- Molecular Weight:342.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
α-MSH (11-13) induces MC1R-dependent calcium signaling and inhibits TNF-α-stimulated NF-κB activation in MC1R-transfected CHO-K1 cells[1].
α-MSH (11-13) inhibits the production of TNF-α, IL-6, and nitric oxide in LPS (HY-D1056)-stimulated mouse microglial cell cultures[1].
α-MSH (11-13) (0-0.1 mM; 2 h) significantly inhibits colony formation of clinical methicillin-resistant Staphylococcus aureus/Candida albicans isolates[3].
α-MSH (11-13) (1 μM; 3 min) significantly increases the level of cAMP accumulation in permeabilized Candida albicans[3].
α-MSH (11-13) (0-0.1 mM; 2 h) enhances the killing activity of human neutrophils against clinical isolates of methicillin-resistant Staphylococcus aureus and Candida albicans[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
α-MSH (11-13) (0.5-200 mg; intracerebroventricular injection, intravenous injection; single administration) dose-dependently reduces leukocytic pyrogen-induced fever in rabbits after central or peripheral administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6N (2-month-old male, 21-35 g, traumatic brain injury induced via controlled cortical impact)[1]
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Dosage:1 mg/kg
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Administration:i.p.; single dose
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Result:Reduced secondary brain contusion volume by 24%.
Decreased microglial activation.
Lowered number of apoptotic neurons.
Did not significantly change neurological severity score.
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Animal Model:New Zealand white (adult)[2]
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Dosage:0.5 mg (i.c.v.); 1.0 mg (i.c.v.); 2.0 mg (i.c.v.); 2 mg (i.v.); 20 mg (i.v.); 200 mg (i.v.)
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Administration:i.c.v.; single dose; i.v.; single dose
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Result:Produced average percent reductions of the area under the control fever curve (over 1.5 hr) of 24% (0.5 mg i.c.v.), 31% (1.0 mg i.c.v.), and 48% (2.0 mg i.c.v.), with each dose significantly more antipyretic than lower doses.
Produced average percent reductions of the area under the control fever curve (over 1.5 hr) of 34% (2 mg i.v.), 27% (20 mg i.v.), and 67% (200 mg i.v.).
Had no effect on body temperature when 200 mg i.v.
dose was administered to afebrile rabbits.
Chemical Information
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CAS No. 67727-97-3
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Molecular Weight 342.43
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Formula C16H30N4O4
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Synonyms
ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OH
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Sequence
Lys-Pro-Val
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Sequence Shortening
KPV
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Schaible EV, et al. Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice. PLoS One. 2013;8(8):e71056. Published 2013 Aug 5. [Content Brief]
[2]. Richards DB, et al. Effect of alpha-MSH 11-13 (lysine-proline-valine) on fever in the rabbit. Peptides. 1984;5(4):815-817. [Content Brief]
[3]. Cutuli M, et al. Antimicrobial effects of alpha-MSH peptides. J Leukoc Biol. 2000 Feb;67(2):233-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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