2. GPCR/G Protein Neuronal Signaling Anti-infection NF-κB Apoptosis Immunology/Inflammation
  3. Melanocortin Receptor Bacterial NF-κB Apoptosis Interleukin Related
  4. α-MSH (11-13)

α-MSH (11-13)  (Synonyms: ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OH)

Cat. No.: HY-129724
Handling Instructions Technical Support

α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-MSH (11-13)

α-MSH (11-13) Chemical Structure

CAS No. : 67727-97-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of α-MSH (11-13):

Other Forms of α-MSH (11-13):

α-MSH (11-13) Related Antibodies

Top Publications Citing Use of Products

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms
MC1R MC3R MC2R MC4R MC5R

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

α-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections[1][2][3].

In Vitro

α-MSH (11-13) induces MC1R-dependent calcium signaling and inhibits TNF-α-stimulated NF-κB activation in MC1R-transfected CHO-K1 cells[1].
α-MSH (11-13) inhibits the production of TNF-α, IL-6, and nitric oxide in LPS (HY-D1056)-stimulated mouse microglial cell cultures[1].
α-MSH (11-13) (0-0.1 mM; 2 h) significantly inhibits colony formation of clinical methicillin-resistant Staphylococcus aureus/Candida albicans isolates[3].
α-MSH (11-13) (1 μM; 3 min) significantly increases the level of cAMP accumulation in permeabilized Candida albicans[3].
α-MSH (11-13) (0-0.1 mM; 2 h) enhances the killing activity of human neutrophils against clinical isolates of methicillin-resistant Staphylococcus aureus and Candida albicans[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-MSH (11-13) Related Antibodies
In Vivo

α-MSH (11-13) (1 mg/kg; i.p.; single administration) reduces the volume of secondary cerebral contusion, alleviates microglial activation, and decreases neuronal apoptosis in a mouse model of traumatic brain injury[1].
α-MSH (11-13) (0.5-200 mg; intracerebroventricular injection, intravenous injection; single administration) dose-dependently reduces leukocytic pyrogen-induced fever in rabbits after central or peripheral administration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6N (2-month-old male, 21-35 g, traumatic brain injury induced via controlled cortical impact)[1]
Dosage: 1 mg/kg
Administration: i.p.; single dose
Result: Reduced secondary brain contusion volume by 24%.
Decreased microglial activation.
Lowered number of apoptotic neurons.
Did not significantly change neurological severity score.
Animal Model: New Zealand white (adult)[2]
Dosage: 0.5 mg (i.c.v.); 1.0 mg (i.c.v.); 2.0 mg (i.c.v.); 2 mg (i.v.); 20 mg (i.v.); 200 mg (i.v.)
Administration: i.c.v.; single dose; i.v.; single dose
Result: Produced average percent reductions of the area under the control fever curve (over 1.5 hr) of 24% (0.5 mg i.c.v.), 31% (1.0 mg i.c.v.), and 48% (2.0 mg i.c.v.), with each dose significantly more antipyretic than lower doses.
Produced average percent reductions of the area under the control fever curve (over 1.5 hr) of 34% (2 mg i.v.), 27% (20 mg i.v.), and 67% (200 mg i.v.).
Had no effect on body temperature when 200 mg i.v.
dose was administered to afebrile rabbits.
Molecular Weight

342.43

Formula

C16H30N4O4
CAS No.
Sequence

Lys-Pro-Val
Sequence Shortening

KPV
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

α-MSH (11-13) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-MSH (11-13)67727-97-3ACTH-(11-13) Lys-Pro-Val H-Lys-Pro-Val-OHMelanocortin ReceptorBacterialNF-κBApoptosisInterleukin RelatedMC ReceptorNuclear factor-κBNuclear factor-kappaBILmicroglial cellsIL-6Candida albicansStaphylococcus aureustraumatic brain injuryTNF-αMC1Rnitric oxideCHO-K1 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
α-MSH (11-13)
Cat. No.:
HY-129724
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.