2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. 3-Phenyltoxoflavin

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity.

For research use only. We do not sell to patients.

3-Phenyltoxoflavin Chemical Structure

3-Phenyltoxoflavin Chemical Structure

CAS No. : 32502-63-9

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 293 In-stock
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1 mg USD 99 In-stock
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Based on 1 publication(s) in Google Scholar

3-Phenyltoxoflavin Related Antibodies

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Description

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].

IC50 & Target[1]

HSP90

585 nM (Kd)

In Vitro

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].
3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Phenyltoxoflavin Related Antibodies
Molecular Weight

269.26

Formula

C13H11N5O2
CAS No.
Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(C1=NC(C2=CC=CC=C2)=NN(C)C1=N3)N(C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (26.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7139 mL 18.5694 mL 37.1388 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

COA (250 KB) HNMR (224 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7139 mL 18.5694 mL 37.1388 mL 92.8471 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL 18.5694 mL
10 mM 0.3714 mL 1.8569 mL 3.7139 mL 9.2847 mL
15 mM 0.2476 mL 1.2380 mL 2.4759 mL 6.1898 mL
20 mM 0.1857 mL 0.9285 mL 1.8569 mL 4.6424 mL
25 mM 0.1486 mL 0.7428 mL 1.4856 mL 3.7139 mL
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3-Phenyltoxoflavin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Phenyltoxoflavin32502-63-9HSPHeat shock proteinsHsp90TPR2AcancerInhibitorinhibitorinhibit

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