2. Neuronal Signaling GPCR/G Protein
  3. Serotonin Transporter 5-HT Receptor
  4. 4-MeO-MiPT

4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values ​​of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values ​​of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression.

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4-MeO-MiPT

4-MeO-MiPT Estructura química

No. CAS : 96096-53-6

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4-MeO-MiPT Related Antibodies

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Descripciòn

4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values ​​of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values ​​of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression[1].

IC50 & Target[1]

5-HT2A Receptor

23 nM (EC50)

5-HT2A Receptor

2.3 nM (pEC50)

In Vitro

4-MeO-MiPT displays nanomolar affinity for multiple serotonin receptor subtypes, SERT, alpha2-adrenergic receptors, and sigma-2 receptors[1].
4-MeO-MiPT is a full agonist at human 5-HT2A receptors and a partial agonist at human 5-HT2B and 5-HT2C receptors, with highest potency at human 5-HT2A and 5-HT2B receptors[1].
4-MeO-MiPT potently inhibits serotonin uptake via SERT in rat brain synaptosomes with an IC50 of 57 nM, and has no meaningful activity at DAT or NET[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-MeO-MiPT Related Antibodies
In Vivo

4-MeO-MiPT (0.03-30 mg/kg; s.c.; single dose) induces 5-HT2A receptor-mediated psychedelic-like effects in mice with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs/30 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male and female, 8 weeks of age)[1]
Dosage: 0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg
Administration: s.c.; single dose
Result: Induced a dose-dependent increase in HTR counts, with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs per 30 minutes.
Increased HTR counts relative to 30 mg/kg 4-MeO-MiPT alone when preceded by 3 mg/kg WAY100635 (HY-10349) pretreatment.
Peso molecular

246.35

Fòrmula

C15H22N2O
No. CAS
SMILES

COC1=C2C(CCN(C(C)C)C)=CNC2=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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4-MeO-MiPT Related Classifications

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Keywords:

4-MeO-MiPT96096-53-6Serotonin Transporter5-HT Receptor5-HTTSERTSLC6A4Serotonin Receptor5-hydroxytryptamine Receptor5-HT2Cmouseserotonin transporterserotonin 2A receptorratalpha2-adrenergic receptors5-HT2B5-HT2A5-HT1AInhibitorinhibitorinhibit

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4-MeO-MiPT
Cat. No.:
HY-W682464
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