4-MeO-MiPT
4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression.
For research use only. We do not sell to patients.
- CAS No.: 96096-53-6
- Formula: C15H22N2O
- Molecular Weight:246.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT2A Receptor 23 nM (EC50) |
5-HT2A Receptor 2.3 nM (pEC50) |
4-MeO-MiPT displays nanomolar affinity for multiple serotonin receptor subtypes, SERT, alpha2-adrenergic receptors, and sigma-2 receptors[1].
4-MeO-MiPT is a full agonist at human 5-HT2A receptors and a partial agonist at human 5-HT2B and 5-HT2C receptors, with highest potency at human 5-HT2A and 5-HT2B receptors[1].
4-MeO-MiPT potently inhibits serotonin uptake via SERT in rat brain synaptosomes with an IC50 of 57 nM, and has no meaningful activity at DAT or NET[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male and female, 8 weeks of age)[1]
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Dosage:0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:s.c.; single dose
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Result:Induced a dose-dependent increase in HTR counts, with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs per 30 minutes.
Increased HTR counts relative to 30 mg/kg 4-MeO-MiPT alone when preceded by 3 mg/kg WAY100635 (HY-10349) pretreatment.
Chemical Information
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CAS No. 96096-53-6
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Molecular Weight 246.35
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Formula C15H22N2O
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SMILES
COC1=C2C(CCN(C(C)C)C)=CNC2=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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