1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Cevimeline hydrochloride

Cevimeline hydrochloride (Synonyms: AF102B hydrochloride)

Cat. No.: HY-70020B Purity: ≥98.0%
Handling Instructions

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Cevimeline hydrochloride Chemical Structure

Cevimeline hydrochloride Chemical Structure

CAS No. : 107220-28-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 96 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 96 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 87 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
50 mg USD 594 Get quote
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Other Forms of Cevimeline hydrochloride:

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Description

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB)[5].

IC50 & Target

Muscarinic M1 and M3 receptor[1]

In Vitro

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage: 0.008 mg/kg, 0.016 mg/kg
Administration: Intraperitoneal injection
Result: Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Clinical Trial
Molecular Weight

235.77

Formula

C10H18ClNOS

CAS No.
SMILES

C[[email protected]]1SC[[email protected]@]2(CN3CCC2CC3)O1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (212.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2414 mL 21.2071 mL 42.4142 mL
5 mM 0.8483 mL 4.2414 mL 8.4828 mL
10 mM 0.4241 mL 2.1207 mL 4.2414 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Cevimeline hydrochloride
Cat. No.:
HY-70020B
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