Cevimeline hydrochloride
Based on 2 publication(s) in Google Scholar
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).
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- Pureté: 98.74%
- CAS No.: 107220-28-0
- Formule: C10H18ClNOS
- Masse moléculaire:235.77
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cevimeline hydrochloride
More
Activité biologique
Description
IC50 & Target
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mAChR1 |
mAChR3 |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-II[1]
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Dosage:0.008 mg/kg, 0.016 mg/kg
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Administration:Intraperitoneal injection
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Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Chemical Information
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CAS No. 107220-28-0
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Appearance Solid
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Masse moléculaire 235.77
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Formule C10H18ClNOS
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Color White to off-white
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SMILES
C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl
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Synonyms
AF102B hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Cell
2025 Nov 10;43(11):2089-2105.e10. PMID: 40829591 -
Cell Rep
Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception. [Abstract]2025 Oct 28;44(10):116294. PMID: 40971298
Solvant et solubilité
In Vitro:
H2O : ≥ 50 mg/mL (212.07 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9. [Content Brief]
[2]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14. [Content Brief]
[3]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17. [Content Brief]
[4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9. [Content Brief]
[5]. Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 4.2414 mL | 21.2071 mL | 42.4142 mL | 106.0355 mL |
| 5 mM | 0.8483 mL | 4.2414 mL | 8.4828 mL | 21.2071 mL | |
| 10 mM | 0.4241 mL | 2.1207 mL | 4.2414 mL | 10.6036 mL | |
| 15 mM | 0.2828 mL | 1.4138 mL | 2.8276 mL | 7.0690 mL | |
| 20 mM | 0.2121 mL | 1.0604 mL | 2.1207 mL | 5.3018 mL | |
| 25 mM | 0.1697 mL | 0.8483 mL | 1.6966 mL | 4.2414 mL | |
| 30 mM | 0.1414 mL | 0.7069 mL | 1.4138 mL | 3.5345 mL | |
| 40 mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.6509 mL | |
| 50 mM | 0.0848 mL | 0.4241 mL | 0.8483 mL | 2.1207 mL | |
| 60 mM | 0.0707 mL | 0.3535 mL | 0.7069 mL | 1.7673 mL | |
| 80 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3254 mL | |
| 100 mM | 0.0424 mL | 0.2121 mL | 0.4241 mL | 1.0604 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cevimeline hydrochloride Related Classifications
HY-70020B Related Classifications
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