Cat. No.: HY-70020B

Cevimeline hydrochloride

(Synonyms: AF102B hydrochloride)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Purity: 98.74%
CAS No.: 107220-28-0
Formula: C₁₀H₁₈ClNOS
Molecular Weight:235.77

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Cevimeline hydrochloride Chemical Structure

CAS No.: 107220-28-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia^[1]^[2]^[3]^[4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB)^[5].

IC₅₀ & Target

mAChR1

mAChR3

All mAChR Isoforms :

In Vitro

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca²⁺ concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (8-week-old) injected with angiotensin-II^[1]
Dosage:

0.008 mg/kg, 0.016 mg/kg
Administration:

Intraperitoneal injection
Result:

Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.

Chemical Information

CAS No. 107220-28-0
Appearance Solid
Molecular Weight 235.77
Formula C₁₀H₁₈ClNOS
Color White to off-white
SMILES

C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl
Synonyms

AF102B hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Journal Impact Factor

Cancer Cell

Long-range cholinergic input promotes glioblastoma progression. [Abstract]

2025 Aug 12:S1535-6108(25)00330-7. PMID: 40829591
Cell Rep

Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception. [Abstract]

2025 Oct 28;44(10):116294. PMID: 40971298

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (212.07 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.2414 mL

21.2071 mL

42.4142 mL

5 mM

0.8483 mL

4.2414 mL

8.4828 mL

10 mM

0.4241 mL

2.1207 mL

4.2414 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9. [Content Brief]

[2]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14. [Content Brief]

[3]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17. [Content Brief]

[4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9. [Content Brief]

[5]. Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.2414 mL	21.2071 mL	42.4142 mL	106.0355 mL
	5 mM	0.8483 mL	4.2414 mL	8.4828 mL	21.2071 mL
	10 mM	0.4241 mL	2.1207 mL	4.2414 mL	10.6036 mL
	15 mM	0.2828 mL	1.4138 mL	2.8276 mL	7.0690 mL
	20 mM	0.2121 mL	1.0604 mL	2.1207 mL	5.3018 mL
	25 mM	0.1697 mL	0.8483 mL	1.6966 mL	4.2414 mL
	30 mM	0.1414 mL	0.7069 mL	1.4138 mL	3.5345 mL
	40 mM	0.1060 mL	0.5302 mL	1.0604 mL	2.6509 mL
	50 mM	0.0848 mL	0.4241 mL	0.8483 mL	2.1207 mL
	60 mM	0.0707 mL	0.3535 mL	0.7069 mL	1.7673 mL
	80 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3254 mL
	100 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0604 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cevimeline hydrochloride

2 Cited Publications

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Cevimeline hydrochloride

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Publications Citing Use of MedChemExpress (MCE) Cevimeline hydrochloride

All mAChR Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cevimeline hydrochloride

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

CNS-Penetrant Compound Library

Drug Repurposing Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

Drug-Induced Liver Injury (DILI) Compound Library

Rare Diseases Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Heterocyclic Compound Library

Off-patent Drug Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Cevimeline hydrochloride

All mAChR Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cevimeline hydrochloride Related Classifications

HY-70020B Related Classifications