1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. Cevimeline

Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Cevimeline hydrochloride hemihydrate and Cevimeline hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Cevimeline Chemical Structure

Cevimeline Chemical Structure

CAS No. : 107233-08-9

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Description

Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline can cross the blood-brain barrier (BBB)[5].

IC50 & Target

Muscarinic M1 and M3 receptor[1]

In Vitro

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage: 0.008 mg/kg, 0.016 mg/kg
Administration: Intraperitoneal injection
Result: Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Clinical Trial
Molecular Weight

199.31

Formula

C10H17NOS

CAS No.
SMILES

C[C@H]1SC[C@@]2(CN3CCC2CC3)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Cevimeline Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cevimeline
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HY-70020
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