1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Cevimeline hydrochloride hemihydrate

Cevimeline hydrochloride hemihydrate (Synonyms: SNI-2011; AF102B hydrochloride hemihydrate)

Cat. No.: HY-76772 Purity: ≥98.0%
Handling Instructions

Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Cevimeline hydrochloride hemihydrate Chemical Structure

Cevimeline hydrochloride hemihydrate Chemical Structure

CAS No. : 153504-70-2

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Description

Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB)[5].

IC50 & Target

Muscarinic M1 and M3 receptor[1]

In Vitro

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage: 0.008 mg/kg, 0.016 mg/kg
Administration: Intraperitoneal injection
Result: Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Clinical Trial
Molecular Weight

244.78

Formula

C10H17NOS.HCl.1/2H2O

CAS No.
SMILES

C[[email protected]]1SC[[email protected]@]2(CN3CCC2CC3)O1.[H]Cl.[Relative Stereochemistry].[0.5 H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (204.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0853 mL 20.4265 mL 40.8530 mL
5 mM 0.8171 mL 4.0853 mL 8.1706 mL
10 mM 0.4085 mL 2.0427 mL 4.0853 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Cevimeline hydrochloride hemihydrate
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HY-76772
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