2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. (+)-Cevimeline hydrochloride hemihydrate

(+)-Cevimeline hydrochloride hemihydrate  (Synonyms: (+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate)

製品番号: HY-76772A
取扱説明書 Technical Support

(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

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(+)-Cevimeline hydrochloride hemihydrate

(+)-Cevimeline hydrochloride hemihydrate 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 2849 在庫あり
Solution
10 mM * 1 mL in Water USD 2849 在庫あり
Solid
1 mg $672 在庫あり
5 mg $2590 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of (+)-Cevimeline hydrochloride hemihydrate:

(+)-Cevimeline hydrochloride hemihydrate 関連抗体

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mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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製品説明

(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR The general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other tissues were investigated in mice, rats, guinea pigs, rabbits, and dogs. The in vitro metab. of SNI-2011 was also evaluated with rat and dog liver microsomes. After oral administration, plasma concns. of SNI-2011 reached to Cmax within 1 h in both species, suggesting that SNI-2011 was quickly absorbed, and then decreased with a t1/2 of 0.4-1.1 h. The bioavailability was 50% and 30% in rats and dogs, resp. Major metabolites in plasma were both S- and N-oxidized metabolites in rats and only N-oxidized metabolite in dogs, indicating that a large species difference was obsd. in the metab. of SNI-2011. Sex difference was also obsd. in the pharmacokinetics of SNI-2011 in rats, but not in dogs. In the in vitro study, chem. inhibition and pH-dependent studies revealed that the sulfoxidn. and N-oxidn. of SNI-2011 were mediated by cytochrome P 450 (CYP) and flavin-contg. monooxygenase (FMO), resp., in both species. In addn., CYP2D and CYP3A were mainly responsible for the sulfoxidn. in rat liver microsomes.

分子量

244.78

分子式

C10H17NOS.HCl.1/2H2O
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@H](SC1)O[C@]21CN3CCC2CC3.Cl.[0.5H2O]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (408.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0853 mL 20.4265 mL 40.8530 mL
5 mM 0.8171 mL 4.0853 mL 8.1706 mL
10 mM 0.4085 mL 2.0427 mL 4.0853 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0853 mL 20.4265 mL 40.8530 mL 102.1325 mL
5 mM 0.8171 mL 4.0853 mL 8.1706 mL 20.4265 mL
10 mM 0.4085 mL 2.0427 mL 4.0853 mL 10.2133 mL
15 mM 0.2724 mL 1.3618 mL 2.7235 mL 6.8088 mL
20 mM 0.2043 mL 1.0213 mL 2.0427 mL 5.1066 mL
25 mM 0.1634 mL 0.8171 mL 1.6341 mL 4.0853 mL
30 mM 0.1362 mL 0.6809 mL 1.3618 mL 3.4044 mL
40 mM 0.1021 mL 0.5107 mL 1.0213 mL 2.5533 mL
50 mM 0.0817 mL 0.4085 mL 0.8171 mL 2.0427 mL
60 mM 0.0681 mL 0.3404 mL 0.6809 mL 1.7022 mL
80 mM 0.0511 mL 0.2553 mL 0.5107 mL 1.2767 mL
100 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(+)-Cevimeline hydrochloride hemihydrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Cevimeline hydrochloride hemihydrate(+)-SNI-2011 (+)-AF102B hydrochloride hemihydratemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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製品名:
(+)-Cevimeline hydrochloride hemihydrate
製品番号:
HY-76772A
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