Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia
- Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894.
- 1. Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA. [email protected]
Background: We assessed the effectiveness of cevimeline 30 mg 3 times daily in patient-reported oral health (Oral Health Impact Profile [OHIP-49]) and quality of life (QOL) in patients with xerostomia.
Methods: In our investigator-initiated, multicenter, randomized, double-blind, placebo-controlled study, patients who received >40 Gy of radiation therapy to the head and neck including at least 3 major salivary glands were randomized to cevimeline 30 mg or placebo orally 3 times daily for 6 weeks. Patients had to have grade 1 or 2 xerostomia and be >16 weeks posttreatment. Clinical data were collected and questionnaires administered at baseline and week 6. The primary outcome was change in OHIP-49 total score from baseline to week 6.
Results: No statistically significant differences in oral health or QOL were observed. During the 6 weeks of the study, the severity of xerostomia decreased from baseline.
Conclusions: Xerostomia is a significant sequela of treatment of head and neck Cancer that may improve with time. The role of oral parasympathetic muscarinic secretogogues in alleviating patient symptoms and complaints remains unclear.