Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4595)
Related Products (4595)
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TNG-0746132
0 ImagesTNG-0746132 can be used for synthesis of the compound with anticancer activity.
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Dimethylpropiothetin hydrochloride
0 ImagesSynonyms: s,s-Dimethyl-β-propionic acid thetineDimethylpropiothetin hydrochloride is a dimethylsulfide precursor. Dimethylpropiothetin hydrochloride can be isolated from the marine coccolithophore Hymenomonas carterae. Dimethylpropiothetin hydrochloride participates in the maintenance of cellular osmotic pressure.
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Dexamethasone 9,11-epoxide
0 ImagesDexamethasone 9,11-epoxide is a type of glucocorticoid. Dexamethasone 9,11-epoxide can be used as a drug intermediate to prepare Dexamethasone (HY-14648) and Betamethasone (HY-13570). Dexamethasone 9,11-epoxide can be employed in the research of inflammation and immune diseases.
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Fosamprenavir Calcium Salt
0 ImagesSynonyms: GW433908GFosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection.
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MN714
0 ImagesCat. No.: HY-156373Purity: 99.12%MN714 is a prodrug of MN551 (HY-156395) with enhanced cell permeability. MN714 specifically and covalently binds to SOCS2 within living cells, with an EC50 of 3.77 μM at 2 h and 2.52 μM at 8 h. MN714 serves as a chemical probe for investigating the biological mechanisms of the SOCS2 and CRL5 complex, and also functions as an E3 ligase linker for PROTAC development.
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Tropic acid
0 ImagesSynonyms: DL-Tropic acidTropic acid (DL-Tropic acid) is an active small molecule that can be used as the pharmaceutical intermediate.
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(S)-1-Benzylpyrrolidin-3-ol
0 Images(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322).
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3-Carboxy-6-hydroxycoumarin
0 Images3-Carboxy-6-hydroxycoumarin is an intermediate in organic syntheses.
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Boc-L-2,4-Diaminobutyric acid
0 ImagesSynonyms: N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OHBoc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS.
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1-Benzylpyrrole-2,5-dione
0 ImagesSynonyms: N-Benzylmaleimide1-Benzylpyrrole-2,5-dione (N-Benzylmaleimide) is a heterocyclic compound containing a maleimide ring and a benzyl group. 1-Benzylpyrrole-2,5-dione can be used as a key reactant for the green chemical modification of cellulose nanocrystals (CNC).
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N-Boc-5-bromoindole
0 ImagesN-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination.
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BIBR 1087 SE
0 ImagesCat. No.: HY-W004360CAS No.: 212321-78-3Synonyms: Desethyl Dabigatran EtexilateBIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.
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2'-Hydroxy-5'-methylacetophenone
0 Images2'-Hydroxy-5'-methylacetophenone belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
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5-Bromopentanoic acid
0 Images5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria.
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3,5-Dimethylisoxazole-4-boronic acid pinacol ester
0 Images3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of bromodomain inhibitors.
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GL67 pentahydrochloride
0 ImagesCat. No.: HY-149037APurity: 99.95%Synonyms: N4-Spermine cholesteryl carbamate pentahydrochlorideGL67 pentahydrochloride (N4-Spermine cholesteryl carbamate pentahydrochloride) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 pentahydrochloride enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 pentahydrochloride mediates the transduction of plasmid DNA into cells. GL67 pentahydrochloride can be used in drug delivery-related research.
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4-Phenylurazole
0 ImagesSynonyms: 4-Phenyl-1,2,4-triazolidine-3,5-dione4-Phenylurazole (4-Phenyl-1,2,4-triazolidine-3,5-dione) is an important intermediate. 4-Phenylurazole also serves as a photographic emulsion stabilizer and a lubricant additive.
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Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH
0 ImagesFmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH is a drug intermediate in the synthesis of Tirzepatide. Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor (GLP-1R) agonist.
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2,6-Dichloropurine
0 Images2,6-Dichloropurine is a purine derivative, PDE inhibitor analog, and synthetic intermediate for N7-glycosylated purine nucleosides, nucleosides and nucleotides. 2,6-Dichloropurine is applicable to cancer-related research.
