P2Y Receptor
P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.
The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.
P2Y Receptor Isoform Specific Products
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P2Y Receptor Inhibitors
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P2Y Receptor Agonists
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P2Y Receptor Antagonists
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P2Y Receptor Activators
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P2Y Receptor Modulators
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P2Y Receptor Controls
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P2Y Receptor Ligands
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P2Y Receptor Related Products (229)
Related Products (229)
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Antibodies (2)
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P2Y Receptor Isoform Comparison
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Uridine 5'-diphosphate sodium
0 ImagesCat. No.: HY-W1058220CAS No.: 19817-91-5Synonyms: UDP sodiumUridine-5'-diphosphate (UDP) sodium is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate sodium is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate sodium, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
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P2ry2 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09930P2ry2 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2ry4 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09932P2ry4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Rp-dUTPαS tetrasodium
0 ImagesCat. No.: HY-137616CRp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y2 receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y2-expressing 1321N1 cells with an EC50 of 12.5 μM.
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MRS4833
0 ImagesCat. No.: HY-167855CAS No.: 2801627-78-9MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
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Clopidogrel-13C,d3 sulfate
0 ImagesCat. No.: HY-107867S2CAS No.: 1246814-55-0Clopidogrel-13C,d3 sulfate is the deuterium and 13C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects.
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(±)-Clopidogrel-d4
0 ImagesCat. No.: HY-15283AS1CAS No.: 1219274-95-9Synonyms: (±)-Clopidogrelum-d4(±)-Clopidogrel-d4 ((±)-Clopidogrelum-d4) is the deuterium labeled (±)-Clopidogrel (HY-107867). (±)-Clopidogrel is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel has anti-inflammatory effects.
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Uridine 5'-diphosphate-13C9 dilithium
0 ImagesCat. No.: HY-113359AS1Synonyms: UDP-13C9 dilithiumUridine 5'-diphosphate-13C9 (UDP-13C9 ) dilithium is 13C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
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Uridine 5'-diphosphate
0 ImagesUridine-5'-diphosphate (UDP) is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
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2-Methylthio-AMP sodium
0 ImagesCat. No.: HY-103064CAS No.: 81921-45-12-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation.
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MRS2690 disodium
0 ImagesCat. No.: HY-116295AMRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease.
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P2Y1 antagonist 4
0 ImagesCat. No.: HY-175675CAS No.: 3104888-50-5P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction.
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2-MeSADP
0 ImagesCat. No.: HY-108648ACAS No.: 34983-48-7Synonyms: 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP2-MeSADP is a P2Y receptor agonist, with an EC50 of 5 nM for human P2Y12, EC50 values of 19 nM and 13 nM for human P2Y13, and an EC50 of 6.2 nM for mouse P2Y13. It shows slightly higher selectivity for P2Y12 over human P2Y13. 2-MeSADP triggers increases in intracellular calcium levels, Gi-mediated cAMP inhibition, adenylate cyclase inhibition and downstream signal transduction. 2-MeSADP can be used in research related to glaucoma.
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P2ry13 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09923P2ry13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2ry12 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09920P2ry12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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MRS4608
0 ImagesCat. No.: HY-156203CAS No.: 2370976-04-6MRS4608 (Compound 17) is a selective P2Y14 receptor antagonist with IC50 values of 20 (hP2Y14R) and 21.4 nM (mP2Y14R). MRS4608 has anti-inflammatory activity and can reduce the infiltration of eosinophils. MRS4608 can be used for the researches of inflammation and immunology, such as asthma.
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P2RY1 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09914P2RY1 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2ry14 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09927P2ry14 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2ry12 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09921P2ry12 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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P2Y14 antagonist 1
0 ImagesCat. No.: HY-170950P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury.
