81921-45-1
81921-45-1
Chemical Structure
2-Methylthio-AMP sodium
- CAS No.: 81921-45-1
- Formula:C11H14N5Na2O7PS
- Molecular Weight:437.28
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
InChIKey: ADQMUQNGUFIJGD-IDIVVRGQSA-L
SMILES: O[C@H]1[C@@H](O)[C@H](N2C3=C(N=C2)C(N)=NC(SC)=N3)O[C@@H]1COP(O[Na])(O[Na])=O
Biological Activity: 2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
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2-Methylthio-AMP sodium | 2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation. | |||||||||||||||||||||
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References
- [1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [Content Brief]
- [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [Content Brief]
- [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22. [Content Brief]
Keywords
