2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR
  5. mAChR Isoform
  6. mAChR Inhibitor

mAChR Inhibitor

mAChR Inhibitors (85):

Cat. No. Product Name Effect Purity
  • HY-B0344
    Methscopolamine bromide
    		Inhibitor 99.81%
    Methscopolamine bromide ((-)-Scopolamine methyl bromide; Hyoscine methyl bromide) is a peripherally acting muscarinic receptor (mAChR) antagonist that cannot cross the blood-brain barrier. Methscopolamine bromide blocks the muscarinic negative feedback regulation of acetylcholine release from striatal cholinergic terminals, thereby increasing acetylcholine release in the striatum of freely moving rats. Methscopolamine bromide does not induce motor excitation in freely moving rats, nor does it alter the duration of ethanol-induced loss of righting reflex in mice. Methscopolamine bromide fails to antagonize the arecoline-mediated reduction in the duration of ethanol-induced loss of righting reflex in mice.
  • HY-B0499A
    Otilonium bromide
    		Inhibitor 99.67%
    Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome.
  • HY-113995
    (-)-Vesamicol
    		Inhibitor 99.92%
    (-)-Vesamicol (AH5183) is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty.
  • HY-13204A
    Biperiden
    		Inhibitor 99.74%
    Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
  • HY-107416
    RHC 80267
    		Inhibitor 99.41%
    RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).
  • HY-101858
    BQCA
    		Inhibitor 98.03%
    BQCA a highly selective allosteric modulator of the M1 mAChR.
  • HY-B2070
    Methylbenactyzium Bromide
    		Inhibitor 99.53%
    Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor.
  • HY-116408A
    Propiverine hydrochloride
    		Inhibitor 99.80%
    Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
  • HY-N7004
    Arborine
    		Inhibitor 99.77%
    Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure.
  • HY-100795A
    Pirmenol hydrochloride
    		Inhibitor 99.34%
    Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.
  • HY-B0962
    Piperidolate hydrochloride
    		Inhibitor 99.66%
    Piperidolate hydrochloride is a cholinergic antagonist. Piperidolate hydrochloride prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate hydrochloride causes dose-dependent cardiac depression. Piperidolate hydrochloride can be used for the research of ventricular fibrillation.
  • HY-B1667
    Isopropamide iodide
    		Inhibitor 98.0%
    Isopropamide iodide is a long-acting quaternary anticholinergic agent. Isopropamide iodide is used in peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
  • HY-B1188S
    Propantheline-d3 bromide
    		Inhibitor 99.00%
    Propantheline-d3 (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.
  • HY-B1230
    Camylofine
    		Inhibitor 98.21%
    Camylofin is an antimuscarinic, is a smooth muscle relaxant .
  • HY-B2112
    Valethamate bromide
    		Inhibitor 99.32%
    Valethamate bromide is an ester, serving as an effective rapidly acting anticholinergic antispasmodic and muscle relaxant. Valethamate bromide accelerates labor by improving cervical dilation. Valethamate bromide can significantly shorten the labor process and have fewer side effects.
  • HY-135096
    Amitriptyline-d3 hydrochloride
    		Inhibitor 99.75%
    Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.
  • HY-105545A
    Levetimide
    		Inhibitor 99.96%
    Levetimide is a potent and stereoselective inhibitor of [3H](+)pentazocine binding, with a Ki of 2.2 nM.
  • HY-P1376A
    G-Protein antagonist peptide TFA
    		Inhibitor
    G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis.
  • HY-122520
    Fentonium bromide
    		Inhibitor 98.75%
    Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions, such as unstable bladder.
  • HY-169178
    VU6016235
    		Inhibitor
    VU6016235 is a highly selective, orally available, positive allosteric modulator of the M4 mAChR with in vivo inhibitory potency in animal models of psychosis..