26095-59-0
26095-59-0
Chemical Structure
Otilonium bromide
Synonym(s): Octylonium bromide; SP63
- CAS No.: 26095-59-0
- Formula:C29H43BrN2O4
- Molecular Weight:563.57
IUPAC Name: N,N-diethyl-N-methyl-2-((4-(2-(octyloxy)benzamido)benzoyl)oxy)ethan-1-aminium bromide
InChIKey: VWZPIJGXYWHBOW-UHFFFAOYSA-N
SMILES: O=C(OCC[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1.[Br-]
Biological Activity: Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome[1][2][3].
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Otilonium bromide | 99.67% | Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome. | ||||||||||||||||||||
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Otilonium bromide (Standard) | ≥98% | Otilonium (bromide) (Standard) is the analytical standard of Otilonium (bromide). This product is intended for research and analytical applications. Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome. | ||||||||||||||||||||
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Otilonium-d4 bromide | Otilonium-d4 (bromide) is deuterium labeled Otilonium (bromide). | |||||||||||||||||||||
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References
- [1]. Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12(10): p. 1003-10. [Content Brief]
- [2]. Lindqvist S, et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 Dec;137(7):1134-42.
- [3]. Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117(3): p. 463-470. [Content Brief]
