1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Otilonium bromide

Otilonium bromide (Synonyms: Octylonium bromide; SP63)

Cat. No.: HY-B0499A Purity: 95.07%
Handling Instructions

Octylonium bromide (SP63) is an antimuscarinic used as a spasmolytic agent.

For research use only. We do not sell to patients.

Otilonium bromide Chemical Structure

Otilonium bromide Chemical Structure

CAS No. : 26095-59-0

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Octylonium bromide (SP63) is an antimuscarinic used as a spasmolytic agent. Target: mAChR Octylonium bromide (SP63) inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM) [1]. Octylonium bromide (SP63), a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR). Whole-cell Ba2+ currents (IBa) through Ca2+ channels of voltage-clamped chromaffin cells were blocked by otilonium with an IC50 of 6.4 microM. Octylonium bromide (SP63) inhibited the secretory responses induced by 10 s pulses of 50 microM DMPP with an IC50 of 7.4 nM [2]. Octylonium bromide (SP63) may represent an effective treatment for irritable bowel syndrome because it reduces its predominant symptom (abdominal pain/ discomfort) more than placebo does [3]. Octylonium bromide (SP63) is a spasmolytic agent that blocks L-Type Calcium channels in human colonic smooth muscle. Octylonium bromide (SP63) is safe, well tolerated and superior to placebo in reducing the frequency of abdominal pain, severity of abdominal bloating and protecting from symptom relapse in IBS. These results further confirm that patients with IBS can improve during and following treatment with otilonium bromide [4].

Clinical Trial
Molecular Weight

563.57

Formula

C₂₉H₄₃BrN₂O₄

CAS No.

26095-59-0

SMILES

O=C(OCC[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (195.18 mM; Need ultrasonic and warming)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7744 mL 8.8720 mL 17.7440 mL
5 mM 0.3549 mL 1.7744 mL 3.5488 mL
10 mM 0.1774 mL 0.8872 mL 1.7744 mL
*Please refer to the solubility information to select the appropriate solvent.
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Otilonium bromide
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