2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. BPDA2

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.

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BPDA2 Chemical Structure

BPDA2 Chemical Structure

CAS No. : 2907659-86-1

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BPDA2 Related Antibodies

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Description

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes[1].

In Vitro

BPDA2 (0.2-3.2 μM) inhibits basal activation of Akt and ERK1/2 in a concentration dependent manner[1].
BPDA2 (0.25-4.0 μM; for 10 days) suppresses the anchorage independent growth and cancer stem cell properties of breast cancer cells in a concentration dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPDA2 Related Antibodies

Western Blot Analysis[1]

Cell Line: JIMT-1, MDA-MB468 cell
Concentration: 0.2, 0.4, 0.8, 1.6, 3.2 μM
Incubation Time:
Result: Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
Molecular Weight

398.49

Formula

C24H30O5
CAS No.
SMILES

CCCCCCCCCOC1=CC=C(C=C1C(O)=O)C2=CC=C(C=C2)CC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BPDA2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPDA22907659-86-1BPDA 2BPDA-2SHP2Src homology phosphatase 2PTPN11CompetitiveSHP1SHP1BmitogenicRTKbreast cancerJIMT-1MDA-MB468Inhibitorinhibitorinhibit

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