1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Calcium Channel
  3. Propiverine hydrochloride

Propiverine hydrochloride 

Cat. No.: HY-116408A
Handling Instructions

Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.

For research use only. We do not sell to patients.

Propiverine hydrochloride Chemical Structure

Propiverine hydrochloride Chemical Structure

CAS No. : 54556-98-8

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Description

Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].

In Vitro

Propiverine (10-3000 nM) inhibits the specific binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2].

In Vivo

Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats[1].
Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo[1].

Animal Model: Female adult Sprague-Dawley rats (250-270 g)[1]
Dosage: 5 mg dissolved in distilled water (0.5 mL)
Administration: P.o. once daily for 2 weeks
Result: Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.
Increased plasma epinephrine and norepinephrine levels.
No significant changes were observed in body weight.
Molecular Weight

403.94

Formula

C₂₃H₃₀ClNO₃

CAS No.

54556-98-8

SMILES

O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)OCCC)OC3CCN(CC3)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PropiverinemAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsbladderspasmolyticcalciumanticholinergicantimuscarinicoveractiveblaqdderurinaryincontinenceInhibitorinhibitorinhibit

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Product Name:
Propiverine hydrochloride
Cat. No.:
HY-116408A
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