ADM Antibody (YA7942)
(Synonyms: AM; PAMP)ADM Antibody (YA7942) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ADM.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:250-500 |
Product Details
ADM Antibody (YA7942) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ADM.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 20.2 kDa
Human recombinant protein fragment corresponding to amino acids 22-146 of human ADM produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ADM is an Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels|ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex[1][2].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues -
Isoforms & Post-Translational Modification
P35318: 185 amino acids, molecular weight 20420 Da.
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SwissProt ID
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Synonyms
AM; PAMP
Documentation
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