BFSP1 Antibody (YA8266)
(Synonyms: CP94; CP115; CTRCT33; LIFL-H)BFSP1 Antibody (YA8266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BFSP1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-500 |
Product Details
BFSP1 Antibody (YA8266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BFSP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Human recombinant protein fragment corresponding to amino acids 405-665 of human BFSP1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BFSP1 is required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability[1][2].
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Subcellular Localization
Cell membrane,Cytoplasm,Cytoplasm, cytoskeleton,Cytoplasm, cell cortex
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Expression
Tissue_Specificity: Expressed in the cortex and nucleus of the retina lens (at protein level) -
Isoforms & Post-Translational Modification
Q12934 has three isomers: Q12934-1: 74544 Da (predicted); Q12934-2: 60296 Da (predicted); Q12934-3: 58569 Da (predicted).
Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases丨Myristoylated at Gly-434 following proteolytic cleavage at Asp-433丨Acetylated at Ala-42 following proteolytic cleavage at Leu-41 -
Subunit
Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373)
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SwissProt ID
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Synonyms
CP94; CP115; CTRCT33; LIFL-H
Documentation
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