Calsequestrin 2 Antibody (YA6527)

Calsequestrin 2 Antibody (YA6527) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calsequestrin 2.

Predicted band size: 46 kDa;

O14958

845 [NCBI]

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Function：Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats

Subcellular Localization：Sarcoplasmic reticulum lumen

Isoforms & Post-Translational Modification：O14958 has 2 isomers: O14958-1: 46436 Da (predicted); O14958-2: 38269 Da (predicted).
Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity;N-glycosylated

Subunit：Monomer, homodimer and homooligomer

AA033488 antibody; AW146219 antibody; Calsequestrin 2 (cardiac muscle) antibody; Calsequestrin 2 fast twitch cardiac muscle antibody; Calsequestrin antibody; Calsequestrin cardiac muscle isoform antibody; Calsequestrin fast twitch cardiac muscle antibody; Calsequestrin-2 antibody; Calsequestrin2 antibody; cardCSQ antibody; AA033488 antibody; AW146219 antibody; Calsequestrin 2 (cardiac muscle) antibody; Calsequestrin 2 fast twitch cardiac muscle antibody; Calsequestrin antibody; Calsequestrin cardiac muscle isoform antibody; Calsequestrin fast twitch cardiac muscle antibody; Calsequestrin-2 antibody; Calsequestrin2 antibody; cardCSQ antibody; Cardiac calsequestrin 2 antibody; cardiac muscle isoform antibody; CASQ 2 antibody; CASQ2 antibody; CASQ2_HUMAN antibody; cCSQ antibody; ESTM52 antibody; FLJ26321 antibody; FLJ93514 antibody; PDIB2 antibody;