HEMGN Antibody (YA8412)
(Synonyms: CT155; EDAG; EDAG-1; NDR)HEMGN Antibody (YA8412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HEMGN.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-200 |
Product Details
HEMGN Antibody (YA8412) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HEMGN.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 55.2 kDa
Human recombinant protein fragment corresponding to amino acids 260-484 of human HEMGN produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB)
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia
Induction: Down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). Up-regulated in normal PBMCs by mitogens -
Isoforms & Post-Translational Modification
Q9BXL5: 484 amino acids, molecular weight 55341 Da.
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SwissProt ID
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Synonyms
CT155; EDAG; EDAG-1; NDR
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