IL17B Antibody (YA8280)
(Synonyms: IL-17B; IL-20; NIRF; ZCYTO7)IL17B Antibody (YA8280) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL17B.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
IL17B Antibody (YA8280) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL17B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 20.44 kDa
Full length human recombiant protein of human IL17B produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Interleukin-17B (IL-17B) belongs to the IL-17 cytokine family and is a proinflammatory cytokine. IL-17B is expressed in adult pancreas, small intestine, stomach, spinal cord and testis. And IL-17B is less pronounced expression in prostate, colon mucosal lining, and ovary. IL-17B was never detected in activated CD4 T cells[1][2]. IL-17B is secreted as a non-covalent dimer glycoprotein[2]. IL-17B shares about 27% amino acid identity with IL-17A and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β in the THP-1 monocytic cell line[1]. The receptor of IL-17B is IL-17RB, which belongs to the IL-17 receptor family. IL-17B shares IL-17RB with IL-17E. IL-17B inhibits IL-17E binding to IL-17RA/IL-17RB complexes, exhibits protumor roles and IL-17E antitumor activities[2]. IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis[1]. Human and mouse IL-17B shares 88.33% sequence identity.
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary -
Isoforms & Post-Translational Modification
Q9UHF5: 180 amino acids, molecular weight 20437 Da.
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SwissProt ID
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Synonyms
IL-17B; IL-20; NIRF; ZCYTO7
Documentation
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