INPP5F Antibody (YA8785)
(Synonyms: hSAC2; MSTP007; MSTPO47; SAC2)INPP5F Antibody (YA8785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INPP5F.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
INPP5F Antibody (YA8785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INPP5F.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 128.2 kDa
Full length human recombinant protein of human INPP5F produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
INPP5F is an Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries[1][2][3].
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Subcellular Localization
Membrane, clathrin-coated pit,Early endosome,Recycling endosome
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Expression
Tissue_Specificity: Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138) -
Isoforms & Post-Translational Modification
There are four isomers of Q9Y2H2: Q9Y2H2-1: 128407 Da (predicted); Q9Y2H2-2: 43817 Da (predicted); Q9Y2H2-3: 25174 Da (predicted); Q9Y2H2-4: 57800 Da (predicted).
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Subunit
Homodimer (PubMed:25869669)
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SwissProt ID
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Synonyms
hSAC2; MSTP007; MSTPO47; SAC2
Documentation
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