KBTBD4 Antibody (YA8808)
(Synonyms: BKLHD4; HSPC252)KBTBD4 Antibody (YA8808) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KBTBD4.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
KBTBD4 Antibody (YA8808) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to KBTBD4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 58 kDa
Full length human recombinant protein of human KBTBD4 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KBTBD4 is a Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation. RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1. Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1. Degradation is dependent on the presence of an ELM2 domain in the target proteins[1][2].
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Isoforms & Post-Translational Modification
Q9NVX7 has three isomers: Q9NVX7-2: 59904 Da (predicted); Q9NVX7-1: 58144 Da (predicted); Q9NVX7-3: 61009 Da (predicted).
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Subunit
Component of the BCR(KBTBD4) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD4 and RBX1
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SwissProt ID
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Synonyms
BKLHD4; HSPC252
Documentation
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