SEC11A Antibody (YA8824)

Cat. No.: HY-P89140: Data Sheet User Guide for Antibodies
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SEC11A Antibody (YA8824) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SEC11A.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SEC11A Antibody (YA8824) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SEC11A.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 20.4 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P67812

Immunogen

Full length human recombinant protein of human SEC11A produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369)

Subcellular Localization：Endoplasmic reticulum membrane

Isoforms & Post-Translational Modification：P67812 has four isomers: P67812-1: 20625 Da (predicted); P67812-2: 17408 Da (predicted); P67812-3: 21454 Da (predicted); P67812-4: 18988 Da (predicted).

Subunit：Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:34388369)

Synonyms

1810012E07Rik; SEC11L1; sid2895; SPC18; SPCS4A

Documentation

User Guide for Antibodies (1077 KB)