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Art. -Nr.: HY-W437598

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5-Iodo-BIIB021

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Based on 1 Customer Validation

5-Iodo-BIIB021 is a HSP90 ligand. 5-Iodo-BIIB021 serves as a Ligand for Target Protein for PROTAC for the synthesis of PROTAC HSP90 degraders, such as PROTAC HSP90 degrader BP3 (HY-115997). 5-Iodo-BIIB021 is applicable to breast cancer research.

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CAS. Nr.: 911397-54-1
Formel: C₁₅H₁₅ClIN₅O
Molecular Weight:443.67

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

5-Iodo-BIIB021 Chemical Structure

CAS. Nr.: 911397-54-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HSP90

Alle HSP Isoform-spezifische Produkte anzeigen :

In Vivo

BIIB021 (60 mg/kg; i.p.; daily; 12 days) achieves a 31.82% tumor inhibition rate in a BALB/c mouse 4T1 breast cancer model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 911397-54-1
Appearance Solid
Molecular Weight 443.67
Formel C₁₅H₁₅ClIN₅O
SMILES

CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)I
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liu Q, et al. Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. European journal of medicinal chemistry. 2022 Jan 15;228:114013. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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5-Iodo-BIIB021

Bioactive Compound Library Max

Bioactive Compound Library

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Target Protein Ligand Library

Metabolic Enzyme Compound Library

Extracellular Vesicles (EVs) Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

5-Iodo-BIIB021

Bioactive Compound Library Max

Bioactive Compound Library

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Target Protein Ligand Library

Metabolic Enzyme Compound Library

Extracellular Vesicles (EVs) Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

5-Iodo-BIIB021 Related Classifications

HY-W437598 Related Classifications