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  3. PROTAC HSP90 degrader BP3

PROTAC HSP90 degrader BP3 

Cat. No.: HY-115997
Handling Instructions

PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell.

For research use only. We do not sell to patients.

PROTAC HSP90 degrader BP3 Chemical Structure

PROTAC HSP90 degrader BP3 Chemical Structure

CAS No. : 2669072-88-0

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Description

PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell[1].

IC50 & Target

HSP90

 

Cereblon

 

In Vitro

PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC50=0.63 µM in MCF-7 cells, IC50=3.53 µM in MDA-MB-231 cells, IC50=0.61 µM in 4T1 cells, IC50=2.95 µM in MDA-MB-468 cells)[1].
PROTAC HSP90 degrader BP3 (2 µM; 6 h) shows degradation activity in the MCF-7 cells (DC50=0.99 µM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 µM
Incubation Time: 6 h
Result: Showed degradation activity in the MCF-7 cells (DC50=0.99 µM).

Cell Viability Assay[1]

Cell Line: 4T1, MDA-MB-468 cells
Concentration: 0.01, 1, 100, 10000 µM
Incubation Time: 72 h
Result: Inhibited the growth of cancer cells (IC50=0.61 µM in 4T1 cells, IC50=2.95 µM in MDA-MB-468 cells).
In Vivo

PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old female BALB/c mice[1]
Dosage: 40 mg/kg
Administration: i.p., daily, 12 days
Result: Inhibited tumor growth and the tumor inhibition rate was 76.41%.
Molecular Weight

641.08

Formula

C32H29ClN8O5

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PROTAC HSP90 degrader BP3
Cat. No.:
HY-115997
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