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Cat. No.: HY-W437598

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5-Iodo-BIIB021

Name: 5-Iodo-BIIB021
Brand: MedChemExpress
SKU: HY-W437598
Price: 144.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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5-Iodo-BIIB021 is a HSP90 ligand. 5-Iodo-BIIB021 serves as a Ligand for Target Protein for PROTAC for the synthesis of PROTAC HSP90 degraders, such as PROTAC HSP90 degrader BP3 (HY-115997). 5-Iodo-BIIB021 is applicable to breast cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 911397-54-1
Formule: C₁₅H₁₅ClIN₅O
Masse moléculaire:443.67

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

5-Iodo-BIIB021 Chemical Structure

CAS No.: 911397-54-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

HSP90

Voir tous les produits spécifiques à Isoform HSP :

In Vivo

BIIB021 (60 mg/kg; i.p.; daily; 12 days) achieves a 31.82% tumor inhibition rate in a BALB/c mouse 4T1 breast cancer model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 911397-54-1
Appearance Solid
Masse moléculaire 443.67
Formule C₁₅H₁₅ClIN₅O
Color White to off-white
SMILES

CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)I
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Protocole

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Liu Q, et al. Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. European journal of medicinal chemistry. 2022 Jan 15;228:114013. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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