Art. -Nr.: HY-N0831

Jaceosidin

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.07%
CAS. Nr.: 18085-97-7
Formel: C₁₇H₁₄O₇
Molecular Weight:330.29

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Jaceosidin Chemical Structure

CAS. Nr.: 18085-97-7

Größe

Preis

Verfügbarkeit

Menge

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Massenanfrage

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression^[1]. Jaceosidin exhibits anti-cancer^[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation^[3].

IC₅₀ & Target^[1]^[3]

Bax

COX-2

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Alle COX Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	27 μM Compound: 43	Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production by Griess reagent based analysis Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production by Griess reagent based analysis	[PMID: 37683361]
HEK-293T	IC₅₀	11.3 μM Compound: 34	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	[PMID: 21650152]
T-cell	IC₅₀	5.8 μM Compound: 12	Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis	[PMID: 31181920]
THP-1	IC₅₀	70.54 μM Compound: Jaceosidin	Cytotoxicity against human THP1 cells after 48 hrs by trypan blue dye exclusion counting method Cytotoxicity against human THP1 cells after 48 hrs by trypan blue dye exclusion counting method	[PMID: 31784199]

In Vitro

Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells^[1].
? Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation^[1].
? Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity^[1].
? Jaceosidin shows cytostatic activity to HES and HESC cells with IC₅₀s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC₅₀, 70.54, 147.14 μM, respectively), after treatment for 48 h^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Hec1A, KLE, HES and HESC cells
Concentration:

3.125, 6.25, 12.5, 25, 50, and 100 μM
Incubation Time:

48 hour
Result:

Showed cytostatic activity to HES and HESC cells with IC₅₀s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC₅₀, 70.54, 147.14 μM).

In Vivo

Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice^[3].
? Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice^[3].
? Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5-week-old male BALB/c mice (23-26 g)^[3]
Dosage:

10 and 20 mg/kg
Administration:

P.O. once a day for 3 days
Result:

Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.

Animal Model:

Male Sprague-Dawley rats (180-200 g)^[3]
Dosage:

20 mg/kg
Administration:

P.O., for 2 hour
Result:

Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.

Chemical Information

CAS. Nr. 18085-97-7
Appearance Solid
Molecular Weight 330.29
Formel C₁₇H₁₄O₇
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- Compositae
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

All Cell Imaging/StainingCell Proliferation/Viability AssayFlow CytometryIFWB

Sort by:

Journal Impact Factor

Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Ind Crops Prod

2025 Dec 11;239:122458.
Cell Mol Neurobiol

MircoRNA-29a in Astrocyte-derived Extracellular Vesicles Suppresses Brain Ischemia Reperfusion Injury via TP53INP1 and the NF-κB/NLRP3 Axis. [Abstract]

2022 Jul;42(5):1487-1500. PMID: 33620674
Toxicol Appl Pharmacol

Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1. [Abstract]

2025 Apr 3:117327. PMID: 40187661

Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Apr 3:117327. [Abstract]

Colony formation assay of PC9-OR cells treated with Osimertinib, Jaceosidin or combined Osimertinib and Jaceosidin.

Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Apr 3:117327. [Abstract]

Effect of Jaceosidin in LCO-OR cells on Osimertinib 72 h.

Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Apr 3:117327. [Abstract]

Cell cycle distribution was analyzed by flow cytometry after 72 h of treatment with 4 μM Osimertinib, 60 μM Jaceosidin, or a combination of both.

Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Apr 3:117327. [Abstract]

Immunofluorescence staining showed cdc2/Cyclin B1 expression after treating with Osimertinib, Jaceosidin (60 μM), or a combination in PC9-OR cells.

Jaceosidin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Apr 3:117327. [Abstract]

Western blot analysis G2/M phase-related protein expressions after treating Osimertinib, Jaceosidin (60 μM), alone or a combination.
Ultrastruct Pathol

The effects of cisplatin and jaceosidin on SH-SY5Y neuroblastoma cells: an electron microscopic, molecular and biochemical study. [Abstract]

2023 Sep 3;47(5):388-397. PMID: 37246956

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (378.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 7.14 mg/mL (21.62 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0276 mL

15.1382 mL

30.2764 mL

5 mM

0.6055 mL

3.0276 mL

6.0553 mL

10 mM

0.3028 mL

1.5138 mL

3.0276 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Woo SM, et al. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chem Biol Interact. 2016 Dec 25;260:168-175. [Content Brief]

[2]. Lee JG, et al. Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem Toxicol. 2013 May;55:214-21. [Content Brief]

[3]. Min SW, et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J Ethnopharmacol. 2009 Sep 25;125(3):497-500. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	3.0276 mL	15.1382 mL	30.2764 mL	75.6911 mL
	5 mM	0.6055 mL	3.0276 mL	6.0553 mL	15.1382 mL
	10 mM	0.3028 mL	1.5138 mL	3.0276 mL	7.5691 mL
	15 mM	0.2018 mL	1.0092 mL	2.0184 mL	5.0461 mL
	20 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7846 mL
DMSO	25 mM	0.1211 mL	0.6055 mL	1.2111 mL	3.0276 mL
	30 mM	0.1009 mL	0.5046 mL	1.0092 mL	2.5230 mL
	40 mM	0.0757 mL	0.3785 mL	0.7569 mL	1.8923 mL
	50 mM	0.0606 mL	0.3028 mL	0.6055 mL	1.5138 mL
	60 mM	0.0505 mL	0.2523 mL	0.5046 mL	1.2615 mL
	80 mM	0.0378 mL	0.1892 mL	0.3785 mL	0.9461 mL
	100 mM	0.0303 mL	0.1514 mL	0.3028 mL	0.7569 mL

Keywords

Jaceosidin

7 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Jaceosidin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Phenols Library

Pyroptosis Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Pancreatic Cancer Compound Library

Mitochondria-Targeted Compound Library

Food-Sourced Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Cell Death Library

Multi-Target Compound Library

Radioprotector Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Jaceosidin

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle COX Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Jaceosidin Related Classifications

Art. -Nr.: HY-N0831