BRD4 Inhibitor-40
BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models.
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- CAS. Nr.: 2994635-04-8
- Formel: C27H32N8O
- Molecular Weight:484.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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BRD4 BD1 16.1 nM (IC50) |
BRD2 BD1 29.35 nM (IC50) |
BRD4 BD2 142.18 nM (IC50) |
BRD2 BD2 302.35 nM (IC50) |
Chemical Information
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CAS. Nr. 2994635-04-8
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Molecular Weight 484.60
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Formel C27H32N8O
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SMILES
CC(N1C2=CC(NC3=NC(CC)=CC(NC4=NN(C)C5=CC=CC=C45)=N3)=CC=C2N(C([C@H]1C)=O)C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BRD4 Inhibitor-40 Related Classifications
HY-173062 Related Classifications
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