Efna5 - ephrin A5 Gene

Also Known as AL-1; Epl7; RAGS; EFL-5; LERK-7; Ephrin-A5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13640

Summary

Enables chemorepellent activity; Ephrin Receptor binding activity; and neurotrophin TrkB receptor binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Apr 2022]

Efna5 Products (3)

mRNA Protein Name
NM_001413234.1 NP_001400163.1 ephrin-A5 isoform 3
NM_010109.4 NP_034239.1 ephrin-A5 isoform 2 precursor
NM_207654.3 NP_997537.1 ephrin-A5 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chemorepellent activity IDA
IDA: Inferred from direct assay
15996548 MGI
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
9053851 MGI
enables neurotrophin TRKB receptor binding IPI
IPI: Inferred from physical interaction
19036963 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9883724 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
9614241 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
11222144 MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus IDA
IDA: Inferred from direct assay
23242526 MGI
acts upstream of or within cellular response to forskolin IDA
IDA: Inferred from direct assay
23242526 MGI
involved in collateral sprouting IDA
IDA: Inferred from direct assay
19036963 MGI
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
9053851 MGI
involved in positive regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
19036963 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17448994 MGI
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
19036963 MGI
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
17448994 MGI
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
17448994 MGI
involved in regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
11089974 MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
17448994 MGI
acts upstream of or within retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
15996548 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
22275477 MGI
involved in synaptic membrane adhesion IEP
IEP: Inferred from expression pattern
22275477 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
22275477 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22275477 MGI
is active in GABA-ergic synapse IEP
IEP: Inferred from expression pattern
22275477 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
22275477 MGI
located in adherens junction IDA
IDA: Inferred from direct assay
23242526 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
23242526 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
23242526 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17448994 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin-A5

  • EPH-related receptor tyrosine kinase ligand 7

Recombinant Efna5 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70194 Ephrin-A5/EFNA5 Protein, Mouse (HEK293, His) O08543 (Q21-Q206) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75232 Ephrin-A5/EFNA5 Protein, Mouse (HEK293, Fc) O08543 (Q21-N203) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04196 EFNA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17198 Efna5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23650 Efna5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Efna5 NCBI NCBI:1946