VCAM1 - Vcam1 vascular cell adhesion molecule 1 Gene

Also Known as VCAM1B

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25361

Summary

Enables Integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Orthologous to human VCAM1 (vascular cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

VCAM1 Products (2)

mRNA Protein Name
NM_012889.2 NP_037021.1 vascular cell adhesion protein 1 precursor
NM_012889.2 NP_037021.1 vascular cell adhesion protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables integrin binding IMP
IMP: Inferred from mutant phenotype
1377031 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cardiac neuron differentiation IMP
IMP: Inferred from mutant phenotype
12486170 RGD
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
1377031 RGD
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
23226762 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
15980038 RGD
involved in cellular response to vascular endothelial growth factor stimulus IEP
IEP: Inferred from expression pattern
23226762 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
10706728 RGD
involved in innervation IMP
IMP: Inferred from mutant phenotype
12486170 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22521742 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19465514 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
19714308 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22433071 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
22218593 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
19199090 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
20128680 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
11870719 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
22521742 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
11870719 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vascular cell adhesion protein 1

  • V-CAM 1

  • VCAM-1

  • vascular cell adhesion protein 1-like

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-108831 Natalizumab Inhibitor 99.10% Unkown

Clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-121705 Propionyl-L-carnitine 95.0% Phase 3
HY-167874 ASP-8731 Inhibitor 98.42% Phase 1
HY-136692 HMR 1031 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (30)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-112868B ABH hydrochloride 99.90% Unkown
HY-N0602 Ginsenoside Rg2 Inhibitor 98.71% Unkown
HY-N2110 Phellopterin 99.94% Unkown
HY-N1353 Rhamnocitrin Inhibitor 99.67% Unkown
HY-N0617 Sanggenon C 98.46% Unkown
HY-N7688 Regaloside B Inhibitor 99.90% Unkown
HY-139702 α5β1 integrin agonist-1 99.67% Unkown
HY-W588250 Surfactin C1 Antagonist 99.31% Unkown
HY-14921 Elsibucol Inhibitor 99.35% Unkown
HY-N0887 Isoastragaloside I 99.49% Unkown
HY-P11445 GREDVGC 99.45% Unkown
HY-P11088A VCAM1 binding peptide acetate Ligand 99.76% Unkown
HY-RS17114 Vcam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119142 CP-664511 Antagonist / Unkown
HY-143243 Antioxidant agent-5 Inhibitor / Unkown
HY-159179 α4 integrin receptor antagonist 3 Inhibitor / Unkown
HY-163712S 17-Epiestriol-d5-1 / Unkown
HY-170916 Angiogenesis inhibitor 7 Inhibitor / Unkown
HY-171216 GW559090 Antagonist / Unkown
HY-N0602R Ginsenoside Rg2 (Standard) Inhibitor / Unkown
HY-N10047 7,8-Didehydrocimigenol Inhibitor / Unkown
HY-N1990R Gypenoside XLIX (Standard) Activator / Unkown
HY-P11088 VCAM1 binding peptide Ligand / Unkown
HY-P11887 VHPKQHR Ligand / Unkown
HY-RS15618 VCAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112868A ABH Inhibitor / Unkown
HY-163712 17-Epiestriol Agonist / Unkown
HY-183448 ETMTC / Unkown
HY-183516 Osteoprotegerin / Unkown
HY-RS23559 Vcam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-108831A Natalizumab (Anti-CD49d) Inhibitor 99.71% Unkown
HY-P990294 Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens VCAM1 NCBI NCBI:7412