VCAM1 - vascular cell adhesion molecule 1 Gene
Also Known as CD106; INCAM-100
Species: Homo sapiens
About VCAM1
This gene has 6 transcripts (splice variants), 205 orthologues and 36 paralogues. Biased expression in spleen (RPKM 208.8), lymph node (RPKM 52.3) and 7 other tissues.
Summary
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
VCAM1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001078.4 | NP_001069.1 | vascular cell adhesion protein 1 isoform a precursor |
| NM_001199834.2 | NP_001186763.1 | vascular cell adhesion protein 1 isoform c precursor |
| NM_080682.3 | NP_542413.1 | vascular cell adhesion protein 1 isoform b precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cell adhesion mediator activity |
IDA
IDA: Inferred from direct assay
|
22970700 | GOA |
| enables cell adhesion molecule binding |
IDA
IDA: Inferred from direct assay
|
1377228 | GOA |
| enables cell adhesion molecule binding |
IPI
IPI: Inferred from physical interaction
|
12082081 | GOA |
| enables integrin binding |
IDA
IDA: Inferred from direct assay
|
1377228 | GOA |
| enables integrin binding |
IMP
IMP: Inferred from mutant phenotype
|
19738201 | GOA |
| enables primary methylamine oxidase activity |
IDA
IDA: Inferred from direct assay
|
23474851 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
23474851 | GOA |
| part of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex |
IDA
IDA: Inferred from direct assay
|
15220135 | GOA |
| located in apical part of cell |
IDA
IDA: Inferred from direct assay
|
12082081 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
1715889 | GOA |
| located in early endosome |
IDA
IDA: Inferred from direct assay
|
23474851 | GOA |
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
23474851 | GOA |
| located in external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
1377228 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
9290466 | GOA |
| located in filopodium |
IDA
IDA: Inferred from direct assay
|
12082081 | GOA |
| located in microvillus |
IDA
IDA: Inferred from direct assay
|
12082081 | GOA |
| located in podosome |
IDA
IDA: Inferred from direct assay
|
15220135 | GOA |
VCAM1 Protein Structure
I-set: Immunoglobulin I-set domain (28 - 112)
C2-set: Immunoglobulin C2-set domain (133 - 221)
Ig_2: Immunoglobulin domain (227 - 308)
I-set: Immunoglobulin I-set domain (321 - 399)
C2-set: Immunoglobulin C2-set domain (421 - 509)
Ig_2: Immunoglobulin domain (515 - 595)
I-set: Immunoglobulin I-set domain (612 - 685)
- 0
- 200
- 400
- 600
- 739 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
vascular cell adhesion protein 1 |
|
Recombinant VCAM1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7777 | VCAM-1/CD106 Protein, Human (HEK293, His) | P19320 (F25-E698) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73468 | VCAM-1/CD106 Protein, Human (HEK293, Fc) | P19320 (F25-P697) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78948 | VCAM-1/CD106 Protein, Human (Biotinylated, HEK293, hFc) | NP_001069.1/P19320 (F25-P697) | ≥ 95%, as determined by reducing SDS-PAGE. |
VCAM1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80927 | VCAM1 Antibody (YA017) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80927A | VCAM1 Antibody (YA017)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P84155 | VCAM1 Antibody (YA3852) | WB, ICC/IF, FC, ELISA | Human, Rat, Monkey |
| HY-P84155A | VCAM1 Antibody (YA3852)(PBS only) | WB, ICC/IF, FC, ELISA | Human, Rat, Monkey |
| HY-P85406 | VCAM1 Antibody (YA5098) | WB, IHC-P, ICC/IF, IP, FC, IF-Tissue | Human, Mouse, Rat |
| HY-P86133 | VCAM1 Antibody (YA5825) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Viral Encephalitis |
|
|
| Chronic Venous Insufficiency |
|
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| Leukostasis |
|
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| Arteriosclerosis Obliterans |
|
|
| Severe Pre-Eclampsia |
|
|
| Rhinitis |
|
|
| Shwartzman Phenomenon |
|
|
| Arteriosclerosis |
|
|
| Rheumatoid Vasculitis |
|
|
| Oral Lichen Planus |
|
|
| Mooren'S Ulcer |
|
|
| Vascular Disease |
|
|
| Vasculitis |
|
|
| Mild Pre-Eclampsia |
|
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| Fatty Liver Disease |
|
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| Rheumatoid Arthritis |
|
|
| Allergic Rhinitis |
|
|
| Atherosclerosis Susceptibility |
|
|
| Malaria |
|
|
| Venous Insufficiency |
|
|
| Synovitis |
|
|
| Asthma |
|
|
| Carotid Stenosis |
|
|
| Antiphospholipid Syndrome |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Hyperhomocysteinemia |
|
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| Goodpasture Syndrome |
|
|
| Sickle Cell Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Glomerulonephritis |
|
|
| Pre-Eclampsia |
|
|
| Polyarteritis Nodosa |
|
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| Hemoglobinopathy |
|
|
| Allergic Contact Dermatitis |
|
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| Liver Disease |
|
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| Allergic Asthma |
|
|
| Henoch-Schoenlein Purpura |
|
|
| Rheumatic Heart Disease |
|
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| Arthritis |
|
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| Takayasu Arteritis |
|
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| Hyperglycemia |
|
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| Encephalitis |
|
|
| Erythema Nodosum |
|
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| Acute Chest Syndrome |
|
|
| Keratoconjunctivitis |
|
|
| Thrombosis |
|
|
| Cardiovascular System Disease |
|
|
| Alpha-Thalassemia |
|
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| Type 2 Diabetes Mellitus |
|
|
| Sleep Apnea |
|
|
| Systemic Lupus Erythematosus |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Kawasaki Disease |
|
|
| Buerger Disease |
|
|
| Aortic Atherosclerosis |
|
|
| Endocarditis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Multiple Sclerosis |
|
|
| Graves' Disease |
|
|
| Microvascular Complications Of Diabetes 5 |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Myocarditis |
|
|
| Fabry Disease |
|
|
| Macular Degeneration, Age-Related, 9 |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Glucose Intolerance |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
|
| Autoimmune Disease |
|
|
| Pyridoxine Deficiency Anemia |
|
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| Inflammatory Bowel Disease |
|
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| Kidney Disease |
|
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| Diabetic Angiopathy |
|
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| Heart Disease |
|
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| Diabetes Mellitus |
|
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| Psoriasis |
|
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| Allergic Disease |
|
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| Peripheral Artery Disease |
|
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| Myocardial Infarction |
|
|
| Colorectal Cancer |
|
|
| Hypertension, Essential |
|
|
| Carotid Artery Disease |
|
|
| Type 1 Diabetes Mellitus 21 |
|
|
| Intermediate Coronary Syndrome |
|
|
| Main Bronchus Cancer |
|
|
| Interstitial Lung Disease 2 |
|
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| Sickle Cell Anemia |
|
|
| Arteries, Anomalies Of |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Autoimmune Disease Of Central Nervous System |
|
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| Dermatitis, Atopic |
|
|
| Myeloma, Multiple |
|
|
| Lipid Metabolism Disorder |
|
|
| Intracranial Berry Aneurysm |
|
|
| Behcet Syndrome |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
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| Connective Tissue Disease |
|
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| Nervous System Disease |
|
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| Skin Disease |
|
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| Eye Disease |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | VCAM1 | MGD | MGI:98926 |
| Rattus norvegicus | VCAM1 | RGD | RGD:3952 |
| Felis catus | VCAM1 | VGNC | VGNC:66930 |
| Macaca mulatta | VCAM1 | VGNC | VGNC:78761 |
| Canis familiaris | VCAM1 | VGNC | VGNC:48240 |
| Others | VCAM1 | NCBI |