IL5RA - interleukin 5 receptor subunit alpha Gene

Also Known as IL5R; CD125; CDw125; HSIL5R3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3568

About IL5RA

Cytogenetic location: 3p26.2 Genomic coordinates (GRCh38): 3:3,066,324-3,110,374 (from NCBI)

This gene has 11 transcripts (splice variants), 116 orthologues and 23 paralogues. Biased expression in lung (RPKM 1.2), prostate (RPKM 0.7) and 13 other tissues.

Summary

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

IL5RA Products (7)

mRNA Protein Name
NM_000564.5 NP_000555.2 interleukin-5 receptor subunit alpha isoform 1 precursor
NM_001243099.2 NP_001230028.1 interleukin-5 receptor subunit alpha isoform 4 precursor
NM_175724.2 NP_783851.1 interleukin-5 receptor subunit alpha isoform 2 precursor
NM_175725.3 NP_783852.1 interleukin-5 receptor subunit alpha isoform 3 precursor
NM_175726.4 NP_783853.1 interleukin-5 receptor subunit alpha isoform 1 precursor
NM_175727.2 NP_783854.1 interleukin-5 receptor subunit alpha isoform 2 precursor
NM_175728.3 NP_783855.1 interleukin-5 receptor subunit alpha isoform 3 precursor

IL5RA Protein Structure

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (129 - 236)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

interleukin-5 receptor subunit alpha

  • CD125 antigen

IL5RA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
IL5RA Q01344 CSF2RB Homo sapiens P32927
Anti Bait CoIP
9516124
Intra
IL5RA Q01344 IL5 Homo sapiens P05113
Saturation Binding
1495999
Intra
IL5RA Q01344 IL5 Homo sapiens P05113
Crosslink
1495999
Intra
IL5RA Q01344 JAK2 Homo sapiens O60674
Anti Bait CoIP
9516124
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL5RA Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72539 IL-5R alpha Protein, Human (HEK293, His) Q01344-1 (D21-E335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74800 IL-5R alpha Protein, Human (Q01344-2, HEK293, His) Q01344-2 (D21-R335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P78162 IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) Q01344-1 (D21-E335) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78471 IL-5R alpha Protein, Human (HEK293, His-Avi) Q01344-1 (D21-E335) ≥ 95%, as determined by Bis-Tris PAGE.

IL5RA Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81483 IL-5 Receptor alpha Antibody (YA1228) IHC-P Human
HY-P81483A IL-5 Receptor alpha Antibody (YA1228)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Hypereosinophilic Syndrome

  • Eosinophilia

  • HES

  • Eosinophilic Leukocytosis

  • Hypereosinophilic Syndrome, Idiopathic

  • Idiopathic Hypereosinophilic Syndrome

  • Disseminated Eosinophilic Collagen Disease

  • Eosinophilic Disorder

  • Disorders With Increased Eosinophil Counts
Esophagitis

  • Acute Esophagitis
Disseminated Eosinophilic Collagen Disease
T2-Low Asthma

  • Type 2 Low Endotype
T2-High Asthma

  • Type 2 High Endotype
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Chronic Asthma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06773 IL5RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174601 Human IL5RA mRNA / Unkown
HY-RS19696 Il5ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26191 Il5ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P9923A Benralizumab (anti-IL5RA ) Inducer 99.60% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IL5RA VGNC VGNC:67780
Rattus norvegicus IL5RA RGD RGD:70938
Canis familiaris IL5RA VGNC VGNC:41991
Mus musculus IL5RA MGD MGI:96558
Bos taurus IL5RA VGNC VGNC:30165
Macaca mulatta IL5RA VGNC VGNC:73731
Others IL5RA NCBI