LSAMP - limbic system associated membrane protein Gene

Also Known as LAMP; IGLON3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4045

About LSAMP

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:115,802,374-116,445,487 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 5 paralogues. Biased expression in brain (RPKM 19.9), prostate (RPKM 5.4) and 9 other tissues.

Summary

This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

LSAMP Products (2)

mRNA Protein Name
NM_001318915.2 NP_001305844.1 limbic system-associated membrane protein isoform 2 precursor
NM_002338.5 NP_002329.2 limbic system-associated membrane protein isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSAMP Protein Structure

I-set

I-set: Immunoglobulin I-set domain (34 - 128)

I-set

I-set: Immunoglobulin I-set domain (132 - 215)

I-set

I-set: Immunoglobulin I-set domain (222 - 305)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
Protein Preferred Names Protein Names

limbic system-associated membrane protein

  • IgLON family member 3

LSAMP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
LSAMP Q13449 CENPV Homo sapiens Q7Z7K6
Y2H Pooling
32814053
Intra
LSAMP Q13449 CENPV Homo sapiens Q7Z7K6
Validated Y2H
32814053
Intra
LSAMP Q13449 CENPV Homo sapiens Q7Z7K6
Y2H Array
32814053
Intra
LSAMP Q13449 THAP3 Homo sapiens Q8WTV1
Y2H Array
32814053
Intra
LSAMP Q13449 THAP3 Homo sapiens Q8WTV1
Y2H Pooling
32814053
Intra
LSAMP Q13449 THAP3 Homo sapiens Q8WTV1
Validated Y2H
32814053
Intra
LSAMP Q13449 NTM Homo sapiens Q9P121
Protein Array
21982860
Intra
LSAMP Q13449 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32814053
Intra
LSAMP Q13449 METTL27 Homo sapiens Q8N6F8
Y2H Array
32814053
Intra
LSAMP Q13449 METTL27 Homo sapiens Q8N6F8
Y2H Pooling
32814053
Intra
LSAMP Q13449 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
Intra
LSAMP Q13449 BECN1 Homo sapiens Q14457
Y2H Array
32814053
Intra
LSAMP Q13449 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSAMP Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70414 LSAMP Protein, Human (HEK293, His) Q13449 (V29-N315) ≥ 95%, as determined by reducing SDS-PAGE.

LSAMP Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P89734 LSAMP Antibody (YA9078) WB, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07850 LSAMP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21636 Lsamp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28154 Lsamp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LSAMP VGNC VGNC:68095
Rattus norvegicus LSAMP RGD RGD:71102
Canis familiaris LSAMP VGNC VGNC:42836
Bos taurus LSAMP VGNC VGNC:106809
Macaca mulatta LSAMP VGNC VGNC:74450
Mus musculus LSAMP MGD MGI:1261760
Others LSAMP NCBI