HDAC-IN-79
Based on 1 publication(s) in Google Scholar
HDAC-IN-79 (compound 4) is an orally active dual xanthine oxidase-HDAC inhibitor (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM;), with significant in vivo anti-hyperuricemia and anti-tumor activities. HDAC-IN-79 is the most potent cell growth inhibitor (IC50=0.706 μM) of leukemia HL60 cells, induces apoptosis and autophagy, and can regulate the expression levels of signature biomarkers associated with intracellular HDAC inhibition.
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- Formel: C23H30N4O4S
- Molecular Weight:458.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-79
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Biologische Aktivität
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HDAC1 134 nM (IC50) |
HDAC2 284 nM (IC50) |
HDAC3 173 nM (IC50) |
HDAC6 1.32 nM (IC50) |
Chemical Information
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Molecular Weight 458.57
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Formel C23H30N4O4S
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SMILES
CC(C)COC1=CC=C(C2=NC(C)=C(C(NCCCCCCC(NO)=O)=O)S2)C=C1C#N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC-IN-79 Related Classifications
HY-162910 Related Classifications
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