country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-164686

Copy Link Print Information

MMV019662

MMV019662 is a PfNCR1 inhibitor and antimalarial agent. MMV019662 reduces gametocytemia levels of Plasmodium falciparum. MMV019662 is applicable to malaria-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 896349-19-2
Formel: C₂₇H₃₅N₃O₄
Molecular Weight:465.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

MMV019662 Chemical Structure

CAS. Nr.: 896349-19-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MMV019662 is a PfNCR1 inhibitor and antimalarial agent. MMV019662 reduces gametocytemia levels of Plasmodium falciparum. MMV019662 is applicable to malaria-related research^[1]^[2].

IC₅₀ & Target^[1]^[2]

Plasmodium

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	Inhibition	1 % Compound: TCMDC-124312	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	[PMID: 20485427]

In Vitro

MMV019662 (3× EC₉₀; 13 days) significantly reduces the total gametocytaemia level of blood-stage gametocytes of Plasmodium falciparum^[1].
MMV019662 (72 h) inhibits the growth of the asexual erythrocytic stage of P. falciparum (Plasmodium falciparum) with an EC₅₀ of 1.18 μM^[1].
MMV019662 (0-100 μM) does not thermostabilize purified PfNCR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 896349-19-2
Molecular Weight 465.59
Formel C₂₇H₃₅N₃O₄
SMILES

O=C(NCC(C1=CC=C2OCOC2=C1)N3CCN(C4=CC=C(OC)C=C4)CC3)C5CCCCC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kohling A, et al. Targeting ligand binding sites in Plasmodium falciparum NCR1 enables antimalarial drug discovery. bioRxiv, 2025: 2025.11. 11.687791.

[2]. Zhang Z, et al. The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis. bioRxiv, 2024: 2024.09. 30.615907.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

MMV019662

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MMV019662 Related Classifications

HY-164686 Related Classifications