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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Mark1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Mark1" in MCE Product Catalog:
3
3 Cited Publications
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability [1].
Target:
Forschungsgebiete:
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively [1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells . MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .
Art. -Nr.: HY-RS08149
Target:
Forschungsgebiete:
MARK1 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS21640
Target:
Forschungsgebiete:
Mark1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mark1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS28158
Target:
Forschungsgebiete:
Mark1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mark1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-120877A
Reinheit: 98.70%
Target:
Forschungsgebiete:
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 [1] .
Art. -Nr.: HY-P701806
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Mark1; PAR1 Homolog C; Microtubule Affinity Regulating Kinase 1; Par1c; MAP/Microtubule Affinity-Regulating Kinase 1; MAP/Microtubule Affinity-Regulating Kinase 1 Isoform A; Mark; Non-Specific Serine/Threonine Protein Kinase; Serine/Threonine-Protein Kina
Species:
Human
Source:
E. coli
Art. -Nr.: HY-P701807
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Mark1; PAR1 Homolog C; Microtubule Affinity Regulating Kinase 1; Par1c; MAP/Microtubule Affinity-Regulating Kinase 1; MAP/Microtubule Affinity-Regulating Kinase 1 Isoform A; Mark; Non-Specific Serine/Threonine Protein Kinase; Serine/Threonine-Protein Kina
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
